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In this retrospective study, we analysed outcomes with combined ibrutinib and venetoclax treatment in these groups of patients. The median treatment\u2010free and overall survival for 22 patients with prior progression on ibrutinib (venetoclax\u2010na\u00efve) were 23.7 and 47.1\u2009months respectively. In 11 patients with double\u2010refractory CLL, the median treatment\u2010free and overall survival were 11.2 and 27.0\u2009months respectively. The combination of ibrutinib and venetoclax may help bridge the current gap in options for patients with disease refractory to the most commonly used novel agents.<\/jats:p>","DOI":"10.1111\/bjh.18357","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T12:15:00Z","timestamp":1657973700000},"page":"239-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Combined ibrutinib and venetoclax for treatment of patients with ibrutinib\u2010resistant or double\u2010refractory chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-3024","authenticated-orcid":false,"given":"Paul J.","family":"Hampel","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari 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