{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:33:01Z","timestamp":1790865181082,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>COVID\u201019 continues to be a relevant issue among patients with haematological malignancies (HM). Vaccines are frequently not effective in subjects on active treatment. In this multicentre retrospective study of Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA), we collected data from 91 paucisymptomatic HM patients treated with anti\u2010spike neutralizing monoclonal antibodies (nMoAbs) to determine time to viral clearance, referencing it to the expected value of 28\u2009days from an historical group of untreated paucisymptomatic patients. Secondary endpoints included rate of hospitalization, intensive care unit (ICU) admission, COVID\u201019 related death and safety. SARS\u2010CoV\u20102 molecular swab negativity was obtained in 86 patients (95%), with a median time of 18\u2009days (IQR 13\u201326; <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001). We did not find significant variations according to age, diagnosis, treatment type, vaccination status or nMoAbs type. Rate of hospitalization due to COVID\u201019 progression was 12% (11\/91), with 2 patients (2.2%) requiring ICU admission. With a median follow\u2010up of 2.33\u2009months, the overall mortality was 5.5% (5\/91), with 3 deaths due to COVID\u201019. Side effects were rare and self\u2010limiting. Our data suggest that nMoAbs can limit the detrimental effect of immunosuppressive treatments on COVID\u201019 clinical progression and time to viral clearance. The original trial was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link> as #NCT04932967.<\/jats:p>","DOI":"10.1111\/bjh.18385","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T11:00:52Z","timestamp":1659178852000},"page":"54-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neutralizing monoclonal antibodies in haematological patients paucisymptomatic for <scp>COVID<\/scp>\u201019: The <scp>GIMEMA EMATO<\/scp>\u20100321 study"],"prefix":"10.1111","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-0785","authenticated-orcid":false,"given":"Vincenzo","family":"Marasco","sequence":"first","affiliation":[{"name":"Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori University of Milano  Milan 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