{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:46:01Z","timestamp":1775245561291,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Thrombosis and haemorrhage are frequent in patients with essential thrombocythaemia (ET). The 2016 revised International Prognostic Score for Thrombosis in Essential Thrombocythaemia\u2010thrombosis (r\u2010IPSET\u2010t) score stratifies patients into very\u2010low\u2010 (VLR), low\u2010 (LR), intermediate\u2010 (IR) and high\u2010risk (HR) groups. We validated the r\u2010IPSET\u2010t in the biggest population of patients with ET (<jats:italic>n<\/jats:italic>\u00a0=\u00a01381) to date and found it to be a better fit than the earlier IPSET\u2010t score. With an average follow\u2010up of 87.7\u2009months, there were 0.578 thrombotic events\/person\u2010year and 0.286 bleeding events\/person\u2010year after diagnosis. The 10\u2010year thrombosis\u2010free survival was 88% and 99% for the r\u2010IPSET\u2010t LR and VLR groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Cytoreduction was a thrombotic risk factor in younger patients (aged &lt;60\u2009years, hazard ratio 9.49, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026; aged \u226560\u2009years, hazard ratio 1.04, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.93). In multivariable Cox regression analysis, anti\u2010aggregation after diagnosis was protective for thrombosis (hazard ratio 0.31, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) but a risk factor for major bleeding (hazard ratio 10.56, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021). Of the IPSET\u2010t HR and LR groups, 132\/780 and 249\/301 were re\u2010classified as LR and VLR respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The European LeukemiaNET (ELN) does not recommend aspirin for VLR patients but in this real\u2010life analysis 83.1% of VLR patients received it. Our results validate the r\u2010IPSET\u2010t score as more predictive for thrombosis than the ELN\u2010recommended IPSET\u2010t and raise concerns about unnecessary cytoreductive and anti\u2010aggregative therapy.<\/jats:p>","DOI":"10.1111\/bjh.18387","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T06:14:00Z","timestamp":1659161640000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Validation of thrombotic risk factors in 1381 patients with essential thrombocythaemia: A multicentre retrospective real\u2010life study"],"prefix":"10.1111","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-2290","authenticated-orcid":false,"given":"Ruth","family":"Stuckey","sequence":"first","affiliation":[{"name":"Hematology Department Hospital Universitario de Gran Canaria Dr. Negr\u00edn  Las Palmas 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Szpital Wojew\u00f3dzki  Opole Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Go\u0142os","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Szukalski","sequence":"additional","affiliation":[{"name":"Department of Haematology CM UMK in Bydgoszcz Nicolaus Copernicus University in Toru\u0144  Toru\u0144 Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas M.","family":"Gonz\u00e1lez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Investigation Unit Hospital Universitario de Gran Canaria Dr. 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