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Therapy choices are dictated by patient characteristics, disease factors and local funding arrangements. The goals of therapy are to eradicate the underlying clone in order to improve quality of life and overall survival. Most evidence has been garnered in the front\u2010line setting. Localised disease responds well to radiotherapy, whilst for those with systemic disease, the best outcomes are demonstrated with induction chemotherapy followed up with high\u2010dose melphalan and stem cell rescue if eligible. For transplant\u2010ineligible patients lenalidomide\u2013dexamethasone remains a preferred treatment option. Data in the relapse setting are scarce. Supportive care including management of neuropathy, endocrinopathy, thrombotic risk and anti\u2010infective agents is necessary. Future international collaboration is crucial to define optimal treatment strategies particularly in the relapse setting.<\/jats:p>","DOI":"10.1111\/bjh.18400","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:04:25Z","timestamp":1659917065000},"page":"128-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evidence\u2010based medical treatment of <scp>POEMS<\/scp> syndrome"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-7828","authenticated-orcid":false,"given":"Jahanzaib","family":"Khwaja","sequence":"first","affiliation":[{"name":"Department of Haematology University College London Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"D'Sa","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals  London 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