{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:28:02Z","timestamp":1782167282771,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA015704"],"award-info":[{"award-number":["P30 CA015704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Currently, there is no convincing evidence that the grade of follicular lymphoma (FL) impacts patient outcome. We correlated grades in 33\u2009925 patients with nodal FL during 1992\u20132018 in the SEER database with disease\u2010specific survival (DSS) and overall survival (OS). Patients with FL grade 3 had lower DSS and OS as compared to FL grades 1\u20132. During 1992\u20132005, the 10\u2010year DSS for patients with FL grades 3 and grades 1\u20132 were 68.6%, and 71.4%, respectively, and in 2006\u20132018, they were 77.7% and 82.6%, respectively. The 10\u2010year OS estimates in 1992\u20132005 were 49.9% and 54.2% for grade 3 and grades 1\u20132 respectively, and in 2006\u20132018, they were 59.1% and 63.5% for grade 3 and grades 1\u20132, respectively. After adjustment for stage and age, the hazard ratios for death due to FL and death from any cause for patients with FL grade 3 during 1992\u20132005 were 1.09 (1.02\u20131.16) and 1.07 (1.02\u20131.12), respectively, compared to FL grades 1\u20132; and during 2006\u20132018, the hazard ratios for death due to FL and death from any cause for patients with FL grade 3 were 1.34 (1.22\u20131.45) and 1.16 (1.10\u20131.23), respectively compared to FL grades 1\u20132. The grade of FL is an important determinant of disease biology.<\/jats:p>","DOI":"10.1111\/bjh.18404","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T01:23:31Z","timestamp":1660699411000},"page":"696-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The impact of histological grade on outcomes in follicular lymphoma: An analysis of patients in the <scp>SEER<\/scp> database in the context of evolving disease classification and treatment"],"prefix":"10.1111","volume":"199","author":[{"given":"Anisha","family":"Naik","sequence":"first","affiliation":[{"name":"Pathology Section, Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Gooley","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics Program, Clinical Research Division Fred Hutchinson 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