{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:04:09Z","timestamp":1785942249463,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00538"],"award-info":[{"award-number":["PI21\/00538"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Available data have proved insufficient to develop consensus recommendations on the prevention of thrombosis and bleeding in myelofibrosis (MF). We evaluated the incidence and risk factors of vascular complications in 1613 patients from the Spanish Myelofibrosis Registry. Over a total of 6981 patient\u2010years at risk, 6.4% of the study population had at least one thrombotic event after MF diagnosis, amounting to an incidence rate of 1.65 per 100 patient\u2010years. Prior history of thrombosis, the <jats:italic>JAK2<\/jats:italic> mutation, and the intermediate\u20102\/high\u2010risk International Prognostic Scoring System (IPSS) categories conferred an increased thrombotic risk after adjustment for the risk\u2010modifying effect of anti\u2010thrombotic and cytoreductive treatments. History of thrombosis and the <jats:italic>JAK<\/jats:italic>2 mutation allowed us to pinpoint a group of patients at higher risk of early thrombosis. No decreased incidence of thrombosis was observed while patients were on anti\u2010thrombotic or cytoreductive treatment. An increased risk of venous thrombosis was found during treatment with immunomodulatory agents. A total of 5.3% of patients had at least one episode of major bleeding, resulting in an incidence rate of 1.5 events per 100 patient\u2010years. Patients in the intermediate\u20102\/high\u2010risk IPSS categories treated with anti\u2010coagulants had an almost sevenfold increased risk of major bleeding. These findings should prove useful for guiding decision\u2010making in clinical practice.<\/jats:p>","DOI":"10.1111\/bjh.18440","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T07:25:11Z","timestamp":1662967511000},"page":"529-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Predictors of thrombosis and bleeding in 1613 myelofibrosis patients from the Spanish Registry of Myelofibrosis"],"prefix":"10.1111","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-3113","authenticated-orcid":false,"given":"Juan\u2010Carlos","family":"Hern\u00e1ndez\u2010Boluda","sequence":"first","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Pastor\u2010Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-7826","authenticated-orcid":false,"given":"Eduardo","family":"Arellano\u2010Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Hemotherapy and Hemostasis Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u2010Mar\u00eda","family":"Raya","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de Canarias  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"P\u00e9rez\u2010Encinas","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2699-8353","authenticated-orcid":false,"given":"Rosa","family":"Ayala","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-3243","authenticated-orcid":false,"given":"Francisca","family":"Ferrer\u2010Mar\u00edn","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Morales Meseguer, Universidad Cat\u00f3lica San Antonio de Murcia, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Velez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Mora","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Laura","family":"Fox","sequence":"additional","affiliation":[{"name":"Hematology Department Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas\u2010Mar\u00eda","family":"Hern\u00e1ndez\u2010Rivas","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-1307","authenticated-orcid":false,"given":"Blanca","family":"Xicoy","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Germans Trias i Pujol, Institut Catal\u00e0 d'Oncologia, Josep Carreras Leukemia Research Institute, Universitat Aut\u00f2noma de Barcelona  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Isabel","family":"Mata\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Costa del Sol  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Garc\u00eda\u2010Fortes","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"P\u00e9rez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Angona","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Josep Trueta, Institut Catal\u00e0 d'Oncologia  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Cuevas","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Sen\u00edn","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Duran i Reynals, Institut Catal\u00e0 d'Oncologia, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Jos\u00e9","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital General Jerez de la Frontera  C\u00e1diz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Ram\u00edrez\u2010Payer","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Central de Asturias  Oviedo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Teresa","family":"G\u00f3mez\u2010Casares","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Dr Negr\u00edn  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Mart\u00ednez\u2010Valverde","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Magro","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Pr\u00edncipe de Asturias  Alcal\u00e1 de Henares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan\u2010Luis","family":"Steegmann","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Antonia","family":"Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Son Espases  Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital General\u2009Universitario de\u2009Alicante  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Gasior","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Gonz\u00e1lez","family":"de Villambrosia","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-4619","authenticated-orcid":false,"given":"Alberto","family":"Alvarez\u2010Larr\u00e1n","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Hemotherapy and Hemostasis Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Spanish MPN Group (GEMFIN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.89"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-782037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-695940"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.0240"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.1925"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5387-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-2102-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404048"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-238956"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.025064"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-0289-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.351"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.258"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0242-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01279-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13721"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.343"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23217"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14754"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.85"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2330-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-394775"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24572"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8081.1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-661835"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03766-z"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.062"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-263319"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405062"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2928"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.6548"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.254"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-325589"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-287417"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0077-1"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0157"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18440","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:33:51Z","timestamp":1692682431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/bjh.18440"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18440","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"assertion":[{"value":"2022-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}