{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:44:15Z","timestamp":1789011855977,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Salvage chemotherapy followed by high\u2010dose chemotherapy and autologous stem cell transplantation (ASCT) is a potentially curative treatment for patients with relapsed or refractory large B\u2010cell lymphoma (rrLBCL) with chemosensitive disease. A<jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (PET) scan after salvage chemotherapy is used to assess response and eligibility for ASCT, but metrics for chemosensitivity in patients with residual disease are not well defined. We performed a single\u2010centre retrospective analysis of 92 patients with a partial response or stable disease after salvage chemotherapy for rrLBCL who received ASCT to investigate PET\u2010derived parameters and their prognostic utility. The Deauville 5\u2010point Scale (D\u20105PS) score, maximum standardised uptake value (SUV<jats:sub>max<\/jats:sub>), total metabolic tumour volume (TMTV), and total lesion glycolysis (TLG) were calculated from the post\u2010salvage\/pre\u2010ASCT PET scan. The 5\u2010year progression\u2010free survival (PFS) and overall survival (OS) rates were 40% and 54% respectively. A D\u20105PS score of 5 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0082, hazard ratio [HR] 2.09), high SUV<jats:sub>max<\/jats:sub> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0015, HR 2.48), TMTV (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.035, HR 1.83) and TLG (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0036, HR 2.27) were associated with inferior PFS. A D\u20105PS score of 5 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030, HR 1.98) and high SUV<jats:sub>max<\/jats:sub> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0025, HR 2.55) were associated with inferior OS. PET\u2010derived parameters may help prognosticate outcomes after ASCT in patients with rrLBCL with residual disease after salvage chemotherapy.<\/jats:p>","DOI":"10.1111\/bjh.18441","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T05:51:08Z","timestamp":1662529868000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Positron emission tomography derived metrics in relapsed or refractory large B\u2010cell lymphoma with residual disease before autologous stem cell transplant"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-8447","authenticated-orcid":false,"given":"Hua\u2010Jay J.","family":"Cherng","sequence":"first","affiliation":[{"name":"Division of Cancer Medicine University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Division of Hematology and Oncology Columbia University Irving Medical Center  New 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