{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:46:30Z","timestamp":1747183590915,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R94\u2010A5768\u2010B2403"],"award-info":[{"award-number":["R94\u2010A5768\u2010B2403"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Overweight patients with cancer are frequently reduced in chemotherapy dose due to toxicity concerns, although previous studies have indicated that dose reduction (DR) of overweight patients results in comparable toxicity but may compromise overall survival (OS). Current evidence regarding DR in patients with acute myeloid leukaemia (AML) is limited. To investigate the association between DR and outcome among overweight patients with AML we analysed a Danish nationwide cohort of overweight adult AML patients treated with remission induction chemotherapy. Among 536 patients identified, 10.1% were categorized as DR defined as 95% or less of full body surface area (BSA)\u2010based dose. Risk factors for DR were high body mass index (BMI) and BSA, therapy\u2010related AML and favourable cytogenetics. No significant differences were observed for rates of complete remission (CR), 30\u2010 and 90\u2010day mortality between DR and non\u2010DR patients. Furthermore, DR did not affect median relapse\u2010free survival (RFS) [DR, 14.5 (95% confidence interval, 9.0\u201341.7) months; non\u2010DR, 15.0 (12.3\u201319.3)] with an adjusted difference in five\u2010year restricted mean survival time (\u03945y\u2010RMST) of 0.2 (\u22128.4 to 8.8) months nor median OS (DR, 17.0 [11.9 to 45.5] months; non\u2010DR, 17.5 [14.8 to 20.5]) with an adjusted \u03945y\u2010RMST of 0.8 (\u22125.7 to 7.3) months. In conclusion, we found no statistically significant association between DR and outcomes among overweight patients with AML. However, we acknowledge the limited sample size and encourage further studies in this important subject.<\/jats:p>","DOI":"10.1111\/bjh.18448","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T21:19:29Z","timestamp":1662758369000},"page":"539-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of chemotherapy dose reductions in overweight patients with acute myeloid leukaemia: A Danish nationwide cohort study"],"prefix":"10.1111","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-7051","authenticated-orcid":false,"given":"Daniel Tuyet","family":"Kristensen","sequence":"first","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars 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\u00d8stergaard","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Sch\u00f6llkopf","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Theilgaard\u2010M\u00f6nch","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarec Christoffer","family":"El\u2010Galaly","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg 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