{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:19:25Z","timestamp":1789183165907,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Our objective was to assess the effect of maternal intravenous immunoglobulin (IVIG) administration for severe red blood cell (RBC) alloimmunisation on fetal outcomes. This is a case\u2013control study. Women with a history of severe early onset alloimmunisation resulting in fetal loss in a previous pregnancy and high anti\u2010D or anti\u2010K antibody titres received IVIG in a subsequent pregnancy. We assessed gestational age at first transfusion and fetal outcomes in the subsequent pregnancy and compared these with the outcomes in the previous pregnancy. The most responsible antibody was anti\u2010D in 17 women and anti\u2010K in two others, whilst seven had more than one antibody. In all, 19 women received IVIG in 22 pregnancies, two of which did not even need an intrauterine transfusion (IUT). For previous early losses despite transfusion, IVIG was associated with a relative increase in fetal haemoglobin between treated and untreated pregnancies of 36.5\u2009g\/L (95% confidence interval 19.8\u201353.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0013) and improved perinatal survival (eight of eight vs. none of six,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001). For previous losses at &lt;20\u2009weeks, it enabled first transfusion deferral in subsequent pregnancies to at least 19.9\u2009weeks (mean 23.2\u2009weeks). Overall, IVIG decreases the severity of haemolytic disease of the fetus and newborn and allows deferral of the first IUT to a safer gestation in severe early\u2010onset RBC alloimmunisation and rarely may even avoid the need for IUT entirely.\n                  <\/jats:p>","DOI":"10.1111\/bjh.18449","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T23:04:03Z","timestamp":1663110243000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Intravenous immunoglobulin in the management of severe early onset red blood cell alloimmunisation"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4330-6862","authenticated-orcid":false,"given":"Evangelia","family":"Vlachodimitropoulou","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Mount Sinai Hospital, University of Toronto  Toronto Ontario 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