{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:42:36Z","timestamp":1692679356878},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To avoid toxicity, patients with inherited intolerance to thiopurines require major dose reductions of six mercaptopurine (6MP) for acute lymphoblastic leukaemia (ALL) maintenance treatment. Germline variants in the <jats:italic>NUDT15<\/jats:italic> gene are emerging as the most common cause of 6MP intolerance in East Asian populations. New approaches are being developed to identify susceptibility to 6MP toxicity in order to appropriately tailor dosing schedules for at\u2010risk patients.<\/jats:p><jats:p>Commentary on: Tanaka et al. Prominence of NUDT15 genetic variation associated with 6\u2010mercaptopurine tolerance in a genome\u2010wide association study of Japanese children with acute lymphoblastic leukaemia. Br J Haematol 2022;199:260\u2010269 and Yoshida et al. Low NUDT15 expression levels due to biallelic NUDT15 variants and 6\u2010mercaptopurine intolerance. Br J Haematol 2022;199:270\u2010276.<\/jats:p>","DOI":"10.1111\/bjh.18451","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T08:24:48Z","timestamp":1663575888000},"page":"173-174","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening for mercaptopurine intolerance in <scp>ALL<\/scp> \u2013 target the genes or their product?"],"prefix":"10.1111","volume":"199","author":[{"given":"John","family":"Barrett","sequence":"first","affiliation":[{"name":"George Washington Cancer Center George Washington University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197102)27:2<247::AID-CNCR2820270202>3.0.CO;2-C"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1416-0"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13518"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3508"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.09.012"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18405"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18375"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T12:53:47Z","timestamp":1692622427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/bjh.18451"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18451","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,19]]},"assertion":[{"value":"2022-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}