{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:14:13Z","timestamp":1789017253897,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Haemophagocytic lymphohistiocytosis\u2010like toxicity following chimeric antigen receptor T cells (CAR\u2010HLH) is being increasingly recognized, while published data are limited and criteria for recognition are elusive. We describe three patients who developed CAR\u2010HLH after infusion of brexucabtagene autoleucel (<jats:italic>n<\/jats:italic>\u00a0=\u20092) or axicabtagene ciloleucel (<jats:italic>n<\/jats:italic>\u00a0=\u20091). All three patients presented following cytokine release syndrome, with fever, recurrent or worsening cytopenias, hyperferritinaemia, elevated soluble interleukin (IL)\u20102 receptor, hypofibrinogenaemia, hypertriglyceridaemia, elevated liver transaminases, and decreasing C\u2010reactive protein and IL\u20106. Clinical improvement following treatment with anakinra (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and ruxolitinib (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) was observed. Our report offers an opportunity for prompt recognition and initiation of potentially life\u2010saving treatment for CAR\u2010HLH.<\/jats:p>","DOI":"10.1111\/bjh.18454","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T07:10:42Z","timestamp":1663312242000},"page":"720-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hyperinflammatory syndrome resembling haemophagocytic lymphohistiocytosis following axicabtagene ciloleucel and brexucabtagene autoleucel"],"prefix":"10.1111","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-5505","authenticated-orcid":false,"given":"Timothy J.","family":"Porter","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Johns Hopkins Hospital  Baltimore Maryland 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