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Over the last decade, epigenomic studies have described the DNA methylome, chromatin accessibility, histone modifications and the three\u2010dimensional (3D) genome architecture of CLL. Beyond its regulatory role, the DNA methylome contains imprints of the cellular origin and proliferative history of CLL cells. These two aspects are strong independent prognostic factors. Integrative analyses of chromatin marks have uncovered novel regulatory elements and altered transcription factor networks as non\u2010genetic means mediating gene deregulation in CLL. Additionally, CLL cells display a disease\u2010specific pattern of 3D genome interactions. From the technological perspective, we are currently witnessing a transition from bulk omics to single\u2010cell analyses. This review aims at summarising the major findings from the epigenomics field as well as providing a prospect of the present and future of single\u2010cell analyses in CLL.<\/jats:p>","DOI":"10.1111\/bjh.18465","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T10:18:30Z","timestamp":1663582710000},"page":"280-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrative epigenomics in chronic lymphocytic leukaemia: Biological insights and clinical applications"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-9620","authenticated-orcid":false,"given":"Marta","family":"Kulis","sequence":"first","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona 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