{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:38Z","timestamp":1787013938093,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U24CA076518"],"award-info":[{"award-number":["U24CA076518"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The prognosis of relapsed\/refractory (R\/R) anaplastic large cell lymphoma (ALCL) is poor. Large studies evaluating outcomes of allogeneic haematopoietic cell transplantation (allo\u2010HCT) in systemic R\/R ALCL are not available. Using the Center for International Blood and Marrow Transplant Research (CIBMTR) database, we evaluated outcomes of 182 adults (aged \u226518\u2009years) with R\/R ALCL undergoing allo\u2010HCT between 2008 and 2019. Non\u2010relapse mortality (NRM), disease relapse\/progression (REL), progression\u2010free survival (PFS), and overall survival (OS) were modelled using Cox proportional hazards models. The median (range) follow\u2010up of survivors was 62\u00a0(3\u2013148)\u00a0months. The 1\u2010year NRM was 18%. The 5\u2010year REL, PFS and OS were 32%, 41% and 56% respectively. On multivariable regression analysis African American race (hazard ratio [HR] 2.7, 95% confidence interval [CI] 1.6\u20134.8;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and refractory disease at allo\u2010HCT (HR 3.2, 95% CI 1.6\u20136.2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) were predictive of inferior OS. Similarly, African\u2010American race (HR 2.1, 95% CI 1.3\u20133.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003), other minority race (HR 2.5, 95% CI 1.2\u20135.3;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.02) and refractory disease (HR 2.2, 95% CI 1.2\u20134.3;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.01) were predictive of inferior PFS. These data, demonstrate that allo\u2010HCT can result in durable disease control in a sizable proportion of patients with R\/R ALCL. Refractory disease and racial minority status predicted inferior allo\u2010HCT outcomes. Whether the inferior outcomes of racial minorities with R\/R ALCL after allo\u2010HCT are driven by differences in disease biology or disparities in post allo\u2010HCT care, or both, requires further investigation.\n                  <\/jats:p>","DOI":"10.1111\/bjh.18467","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T04:49:39Z","timestamp":1663562979000},"page":"54-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Allogeneic haematopoietic cell transplant in patients with relapsed\/refractory anaplastic large cell lymphoma"],"prefix":"10.1111","volume":"200","author":[{"given":"Fateeha","family":"Furqan","sequence":"first","affiliation":[{"name":"BMT &amp; Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang W.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Institute for Health and Equity Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Center for International Blood and Marrow Transplant Research, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A.","family":"Abutalib","sequence":"additional","affiliation":[{"name":"Co\u2010Director, Hematology &amp; BMT\/Cellular Therapy, Medical Director, NMDP Apheresis Midwest Program Associate Professor Rosalind Franklin University of Medicine and Science CTCA, Part of City of Hope  Zion Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nausheen","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Hematologic Malignancies and Cellular Therapeutics University of Kansas Cancer Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-8299","authenticated-orcid":false,"given":"Sairah","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Departments of Lymphoma\/Myeloma and Stem Cell Transplantation\/Cellular Therapy UT MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Kharfan\u2010Dabaja","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology and Blood and Marrow Transplantation and Cellular Therapy Program, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan","family":"Friedberg","sequence":"additional","affiliation":[{"name":"University of Rochester Wilmot Cancer Institute, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Gregory","sequence":"additional","affiliation":[{"name":"Colorado Blood Cancer Institute, Denver CO and Sarah Cannon Research Institute  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaQuisa","family":"Hill","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole","family":"Sterling","sequence":"additional","affiliation":[{"name":"Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan K.","family":"Barta","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazyar","family":"Shadman","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutch Cancer Center and Medical Oncology Division University of Washington  Seattle Washington 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