{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:41:50Z","timestamp":1792446110371,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Belantamab mafodotin, an immuno\u2010conjugate targeting B\u2010cell maturation antigen, showed single\u2010agent activity in phase 1 and 2 studies, and was recently approved for heavily pretreated relapsed\/refractory multiple myeloma (RRMM) patients. Real\u2010world data and long\u2010term follow\u2010up are scarce. We conducted a multisite retrospective study aimed to assess safety and efficacy of belantamab mafodotin monotherapy administered via the GSK expanded access compassionate care programme. One\u2010hundred and six RRMM patients were treated with belantamab mafodotin between July 2019 and March 2021. The median age was 69.4\u2009years. Patients were heavily pretreated with a median of six (range 2\u201311) prior therapy lines. Major adverse effects included ocular toxicity (keratopathy 68.4%, grade \u22653: 40.5%; blurred vision 36.8%, grade \u22653: 6.3%), thrombocytopenia (27.4%, grade \u22653: 17.9%) and infections (11.3%, grade \u22653: 7.5%). Median follow\u2010up time was 11.9 [95% confidence interval (CI) 10.0\u201313.8] months. Overall response rate was 45.5%. Median progression\u2010free survival was 4.7 (95% CI 3.5\u20135.9) months in the entire cohort and 8.8 (95% CI 6.6\u201310.9) months among responders. Median overall survival was 14.5 (95% CI 9.5\u201319.6) months, and not reached for responders. To conclude, in a real\u2010world setting, belantamab mafodotin monotherapy showed efficacy comparable with the prospective clinical trials, with a tolerable toxicity profile.<\/jats:p>","DOI":"10.1111\/bjh.18479","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T07:20:56Z","timestamp":1665127256000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Real\u2010world experience with belantamab mafodotin therapy for relapsed\/refractory multiple myeloma: A multicentre retrospective study"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-689X","authenticated-orcid":false,"given":"Tamir","family":"Shragai","sequence":"first","affiliation":[{"name":"Department of Haematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv 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