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In this setting, this study investigated the efficacy and safety of dasatinib combined to Peg\u2010IFN\u2010\u03b12b (Dasa\u2010PegIFN, NCT01872442). A total of 79 patients (age \u226465\u2009years) started dasatinib; 61 were eligible for Peg\u2010IFN\u03b1\u20102b add\u2010on therapy at month 3 for a maximum 21\u2010months duration. Dasatinib was continued thereafter. The primary endpoint was the cumulative rate of molecular response 4.5 log (MR<jats:sup>4.5<\/jats:sup>) by 12\u2009months. The results are reported for the 5\u2010year duration of the study. Grade 3 neutropenia was frequent with the combination but did not induce severe infection (one of grade 3). Other adverse events were generally low grade (4% of grade 3\u20134) and expected. Seventy\u2010nine per cent and 61% of patients continued the Peg\u2010IFN until months 12 and 24, respectively. Overall, at these time points, MR<jats:sup>4.5<\/jats:sup> rates were 25% and 38%, respectively. Thereafter, 32% and 46% of patients achieved a sustained (\u22652\u2009years) MR<jats:sup>4.5<\/jats:sup> or MR<jats:sup>4<\/jats:sup>, respectively. This work established the feasibility and high rates of achievement of early and sustained DMR (a prerequisite for treatment\u2010free\u2010remission) with dasatinib and Peg\u2010IFN\u03b1\u20102b combination as initial therapy.<\/jats:p>","DOI":"10.1111\/bjh.18486","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T13:30:57Z","timestamp":1665408657000},"page":"175-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dasatinib plus <scp>Peg\u2010Interferon<\/scp> alpha 2b combination in newly diagnosed chronic phase chronic myeloid leukaemia: Results of a multicenter phase 2 study (<scp>DASA\u2010PegIFN<\/scp> study)"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-9673","authenticated-orcid":false,"given":"Lydia","family":"Roy","sequence":"first","affiliation":[{"name":"H\u00f4pital Universitaire Henri Mondor, APHP, Facult\u00e9 de 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