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We extracted data from sixty\u2010five publications (case reports, patient group studies, reviews, and erythrocyte morphology studies). The results show that frequent alterations concern the morphology of lymphocytes (large lymphocytes with weakly basophilic cytoplasm, plasmacytoid lymphocytes, large granular lymphocytes). Neutrophils display abnormal nuclei and cytoplasm in a distinctive cytomorphological picture. Besides a left shift in maturation, granulations can be increased (toxic type) or decreased with areas of basophilia. Nuclei are often hyposegmented (pseudo\u2010Pelger\u2010Hu\u0451t anomaly). Apoptotic or pycnotic cells are not uncommon. Monocytes typically have a large cytoplasm loaded with heterogeneous and coalescing vacuoles. Platelets show large and giant shapes. The presence of erythrocyte fragments and schistocytes is especially evident in the forms of COVID\u201019 that are associated with thrombotic microangiopathies. Such atypia of blood cells reflects the generalized activation in severe COVID\u201019, which has been demonstrated with immunophenotypic, molecular, genetic, and functional methods. Neutrophils, in particular, are involved in the pathophysiology of hyperinflammation with cytokine storm, which characterizes the most unfavorable evolution.<\/jats:p>","DOI":"10.1111\/bjh.18489","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T05:25:45Z","timestamp":1665120345000},"page":"404-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Coronavirus disease 2019 (<scp>COVID<\/scp>\u201019): Focus on peripheral blood cell morphology"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0782-294X","authenticated-orcid":false,"given":"Gina","family":"Zini","sequence":"first","affiliation":[{"name":"Haematology Catholic University of Sacred Heart  Rome Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome 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