{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:29:08Z","timestamp":1774970948292,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Burkitt lymphoma arising in paediatric post\u2010solid\u2010organ transplantation\u2010Burkitt lymphoma (PSOT\u2010BL) is a clinically aggressive malignancy and a rare form of post\u2010transplant lymphoproliferative disorder (PTLD). We evaluated 35 patients diagnosed with PSOT\u2010BL at 14 paediatric medical centres in the United States. Median age at organ transplantation was 2.0\u2009years (range: 0.1\u201314) and age at PSOT\u2010BL diagnosis was 8.0\u2009years (range: 1\u201317). All but one patient had late onset of PSOT\u2010BL (\u22652\u2009years post\u2010transplant), with a median interval from transplant to PSOT\u2010BL diagnosis of 4.0\u2009years (range: 0.4\u201312). Heart (<jats:italic>n<\/jats:italic>\u00a0=\u200918 [51.4%]) and liver (<jats:italic>n<\/jats:italic>\u00a0=\u200913 [37.1%]) were the most frequently transplanted organs. No patients had loss of graft or treatment\u2010related mortality. A variety of treatment regimens were used, led by intensive Burkitt lymphoma\u2010specific French\u2013American\u2013British\/Lymphomes Malins B (FAB\/LMB), <jats:italic>n<\/jats:italic>\u00a0=\u200913 (37.1%), and a low\u2010intensity regimen consisting of cyclophosphamide, prednisone and rituximab (CPR) <jats:italic>n<\/jats:italic>\u00a0=\u200912 (34.3%). Median follow\u2010up was 6.7\u2009years (range: 0.5\u201317). Three\u2010year event\u2010free and overall survival were 66.2% and 88.0%, respectively. Outcomes of PSOT\u2010BL patients receiving BL\u2010specific intensive regimens are comparable to reported BL outcomes in immunocompetent children. Multi\u2010institutional collaboration is feasible and provides the basis of prospective data collection to determine the optimal treatment regimen for PSOT\u2010BL.<\/jats:p>","DOI":"10.1111\/bjh.18498","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T18:58:05Z","timestamp":1669921085000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Burkitt lymphoma after solid\u2010organ transplant: Treatment and outcomes in the paediatric <scp>PTLD<\/scp> collaborative"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-0389","authenticated-orcid":false,"given":"Zeinab","family":"Afify","sequence":"first","affiliation":[{"name":"Pediatric Hematology Oncology Primary Children's Med. 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