{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:38Z","timestamp":1787013938538,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Management of acquired immunodeficiency syndrome (AIDS)\u2010related diffuse large B\u2010cell (DLBCL) and plasmablastic lymphomas (PBL) poses significant challenges. The evidence supports use of dose\u2010adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin) with or without rituximab as first\u2010line therapy. The need for central venous access, growth factors and significant toxicities limits its use in resource\u2010constrained settings. To address these challenges, we have developed a novel regimen, CVEP (cyclophosphamide, vinblastine, etoposide, and prednisolone) based on the pharmacodynamic principles of dose\u2010adjusted EPOCH. This single\u2010centre phase II study evaluated the efficacy and safety of CVEP regimen in patients with de novo systemic AIDS\u2010related DLBCL and PBL. The primary objective was complete response (CR) rates as assessed by positron emission tomography\u2010computed tomography. The secondary objectives were incidence of Grade 3\/4 toxicities, toxicities requiring hospitalisation, and disease\u2010free survival. From May 2011 to February 2017, 42 patients were enrolled. At the end of therapy the CR rates were 69% (29\/42) in the intention\u2010to\u2010treat population and 80.5% (29\/36) in evaluable patients. At a median follow\u2010up of 69\u2009months, the 5\u2010year disease\u2010free survival was 65.3%. Out of 217\u2009cycles administered, febrile neutropenia occurred in 19.3% and hospitalisation was required in 18.3% of cycles. There were two treatment\u2010related deaths. The CVEP regimen is an active and safe regimen for AIDS\u2010related DLBCL and PBL.<\/jats:p>","DOI":"10.1111\/bjh.18532","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T23:34:47Z","timestamp":1667432087000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phase\n                    <scp>II<\/scp>\n                    trial of a novel chemotherapy regimen\n                    <scp>CVEP<\/scp>\n                    (cyclophosphamide, vinblastine, etoposide and prednisolone) for acquired immunodeficiency syndrome\n                    <scp>(AIDS)<\/scp>\n                    \u2010associated lymphomas"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-5682","authenticated-orcid":false,"given":"Manju","family":"Sengar","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-7065","authenticated-orcid":false,"given":"Hasmukh","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuja","family":"Shet","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Epari","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Gota","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha S.","family":"Laskar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Alahari","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashree","family":"Thorat","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archi","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tata Memorial Centre  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Hematology Cancer Consortium  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhana","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikhar","family":"Kumar","sequence":"additional","affiliation":[{"name":"Adult Hematolymphoid Unit, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-795X","authenticated-orcid":false,"given":"Lingaraj","family":"Nayak","sequence":"additional","affiliation":[{"name":"Adult Hematolymphoid Unit, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Haematology &amp; Medical Oncology St. Johns National Academy of Health Sciences  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Gujral","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhausaheb","family":"Bagal","sequence":"additional","affiliation":[{"name":"Adult Hematolymphoid Unit, Tata Memorial Centre A CI of Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000071"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00113-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2171"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21562"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182a39979"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022408"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_452_17"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2339"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.4684"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1437"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.11.3026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.8.2685"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3589"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-498964"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-231613"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-253039"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13221"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27551"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.4213.4213"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90025-B"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01468.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V118.21.2690.2690"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90015-9"},{"key":"e_1_2_9_26_1","unstructured":"HIV Infection: Detection Counseling and Referral \u2010 2015 STD Treatment Guidelines.2019. [cited 2020 Aug 16]. Available from:https:\/\/www.cdc.gov\/std\/tg2015\/hiv.htm"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2019.54.3.181"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2020.106391"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2631"},{"issue":"5","key":"e_1_2_9_30_1","first-page":"719","article-title":"Pharmacology of 21\u2010day oral etoposide given in combination with i.v. cisplatin in patients with extensive\u2010stage small cell lung cancer: a cancer and leukemia group B study (CALGB 9062)","volume":"3","author":"Miller AA","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.1-4-234"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443070-00002"},{"issue":"10","key":"e_1_2_9_33_1","first-page":"2742","article-title":"Inter\u2010 and intrapatient variability in etoposide kinetics with oral and intravenous drug administration","volume":"5","author":"Hande K","year":"1999","journal-title":"Clin Cancer Res"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:03:22Z","timestamp":1692543802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/bjh.18532"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18532","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"2022-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}