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In this study, we compared clinical outcomes of patients with AML with and without <jats:italic>TP53<\/jats:italic> mutations who underwent haploidentical haematopoietic stem cell transplantation (haplo\u2010HSCT). For the <jats:italic>TP53<\/jats:italic>\u2010mutation group and <jats:italic>TP53<\/jats:italic> wild\u2010type group, the 2\u2010year cumulative incidence of relapse (CIR) was (39.0% vs. 21.2% respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.088), the 2\u2010year non\u2010relapse mortality (NRM) rate was (3.2% vs. 8.4% respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.370), the 2\u2010year leukaemia\u2010free survival (LFS) was (57.7% vs. 71.3% respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.205), the 2\u2010year overall survival (OS) rate was (69.9% vs. 81.3% respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.317), the 100\u2010day cumulative incidence of Grade II\u2013IV acute graft\u2010versus\u2010host disease (GvHD) was (6.5% vs. 20.7% respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.074), the 2\u2010year cumulative incidence of chronic GvHD was (52.3% vs. 53.1% respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.493) and the 2\u2010year GvHD\u2010free\/relapse\u2010free survival (GRFS) was (57.7% vs. 69.6% respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.347). Our data showed that there were no significant differences in 2\u2010year clinical outcomes between the two groups. Multivariable analysis showed <jats:italic>TP53<\/jats:italic> mutations had no significant impact on CIR, NRM, OS, GvHD, LFS or GRFS. Our findings suggest that patients with AML with <jats:italic>TP53<\/jats:italic> mutations may at least partially benefit from haplo\u2010HSCT. Haplo\u2010HSCT might be the recommended treatment for such patients.<\/jats:p>","DOI":"10.1111\/bjh.18538","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T09:34:04Z","timestamp":1667900044000},"page":"494-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Haploidentical haematopoietic stem cell transplantation for TP53\u2010mutated acute myeloid leukaemia"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-8781","authenticated-orcid":false,"given":"Ting","family":"Huang","sequence":"first","affiliation":[{"name":"Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation National Clinical Research Center for Hematologic Disease, Peking University People's Hospital, Peking University Institute of Hematology  Beijing P.R. 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