{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:22:53Z","timestamp":1773685373436,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Over the last decade, treatment of immune thrombocytopenia (ITP) in children has advanced to include thrombopoietin receptor agonist (TPO\u2010RA) medications. Concurrently, there has been an increased emphasis on patient\u2010reported outcomes\u2014especially quality of life\u2014to guide treatment. Assessing the impact of TPO\u2010RAs on quality of life in paediatric ITP is therefore a priority. In this single\u2010centre integrative mixed\u2010methods study, a cohort of children with ITP prescribed a TPO\u2010RA was identified. These children and\/or their caregivers were invited to participate in semi\u2010structured interviews focussed on quality\u2010of\u2010life measures. Independently, a retrospective chart review collected ITP\u2010related data (platelet count, bleeding events) and TPO\u2010RA data (dosing, side effects). Among the 23 eligible patients, 20 were represented in interviews. On chart review, 11\/20 patients responded to TPO\u2010RA by meeting platelet count criteria of \u226550\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L for six or more weeks in the absence of rescue therapy. In interviews with these children and\/or their parents, 19\/20 expressed the TPO\u2010RA had \u2018worked\u2019, with 11\/20 reporting benefit to mood and 11\/20 reporting increased participation in activities\/sports. Concerns were raised in interviews about TPO\u2010RA medication cost (17\/20), medication administration (10\/20) and potential side effects (10\/20). In conclusion, this study suggests that TPO\u2010RA use in children with ITP improves quality of life.<\/jats:p>","DOI":"10.1111\/bjh.18545","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T09:43:37Z","timestamp":1667900617000},"page":"506-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating the impact of thrombopoietin receptor agonist medications on patient outcomes and quality of life in paediatric immune thrombocytopenia through <scp>semi\u2010structured<\/scp> interviews"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-4456","authenticated-orcid":false,"given":"Joel","family":"Livingston","sequence":"first","affiliation":[{"name":"The Hospital for Sick Children (SickKids) The University of Toronto  Toronto Ontario Canada"},{"name":"Department of Pediatrics The University of Alberta  Alberta Edmonton 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