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In this issue, Zhou et al. demonstrate that HHV\u20108\u2010infected lambda\u2010restricted plasmablasts can be detected in these effusions and can be used to distinguish MCD from other HHV\u20108 tumours as well as to categorise KICS into distinct clinicopathological groups. These findings open a path to an integrated clinicopathological approach to HHV\u20108\u2010associated inflammatory diseases and may have clinical implications.<\/jats:p><jats:p>Commentary on: Zhou et al. A novel approach for characterisation of KSHV\u2010associated multicentric Castleman disease from effusions. 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