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Despite increasing body mass index (BMI) in the general population, the prevalence of overweight and obese status remains unclear in the adult SCD population. Our primary aim was to determine the prevalence of overweight and obese status and to identify associations between BMI, demographic, and clinical characteristics. We conducted an analysis of abstracted electronic health record data and patient\u2010reported outcomes from the Sickle Cell Disease Implementation Consortium registry; individuals aged 20\u201345\u2009years were included. The median (interquartile range) BMI for the 1664 adults in this analysis was 23.9\u00a0(21.1\u201328)\u00a0kg\/m<jats:sup>2<\/jats:sup>. In this cohort, 42.9% had a BMI of &gt;25\u2009kg\/m<jats:sup>2<\/jats:sup> (Centers for Disease Control and Prevention definition of overweight\/obese). In multivariable analysis, higher odds of being overweight or obese were associated with female gender, older age, college education, private insurance, and hypertension diagnosis. Higher odds of a BMI of &gt;25\u2009kg\/m<jats:sup>2<\/jats:sup> were observed in individuals with HbSC or HbS\u03b2<jats:sup>+<\/jats:sup> thalassaemia regardless of hydroxycarbamide (hydroxyurea) exposure (odds ratio [OR] 3.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and HbSS or HbS\u03b2<jats:sup>0<\/jats:sup> thalassaemia exposed to hydroxycarbamide (OR 1.6, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0003) compared to those with HbSS or HbS\u03b2<jats:sup>0<\/jats:sup> thalassaemia with no hydroxycarbamide exposure. These data highlight the importance of early identification, prevention, and intervention for increasing BMI to reduce obesity\u2010related complications that may impact SCD\u2010related complications.<\/jats:p>","DOI":"10.1111\/bjh.18548","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T08:25:16Z","timestamp":1668587116000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterising the prevalence of overweight and obese status among adults with sickle cell disease"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-9924","authenticated-orcid":false,"given":"Stephanie O.","family":"Ibemere","sequence":"first","affiliation":[{"name":"Duke University School of Nursing  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charity I.","family":"Oyedeji","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Preiss","sequence":"additional","affiliation":[{"name":"RTI International  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Van Althuis","sequence":"additional","affiliation":[{"name":"Duke Office of Clinical Research  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-7321","authenticated-orcid":false,"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Azul","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebony N.","family":"Burns","sequence":"additional","affiliation":[{"name":"Duke University School of Nursing  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Glassberg","sequence":"additional","affiliation":[{"name":"Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ward","family":"Hagar","sequence":"additional","affiliation":[{"name":"University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiz","family":"Hussain","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"King","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Melvin","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Myers","sequence":"additional","affiliation":[{"name":"Duke University School of Nursing  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Snyder","sequence":"additional","affiliation":[{"name":"Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmish","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke University Hospital  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Duke University School of Nursing and Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Sickle Cell Disease Implementation Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Centers for Disease Control and Prevention.All About Adult BMI.Centers for Disease Control and Prevention. 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