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To eliminate compounding effects, a uniform conditioning regimen containing antithymocyte globulin (ATG) was used. After transplantation, there was a significantly higher cumulative incidence of acute graft\u2010versus\u2010host disease (GVHD) in HF\u2010HCT patients (49%, 7%, and 16% for HF\u2010, MS\u2010 and UD\u2010HCT respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). A quarter of acute GVHD cases observed in HF\u2010HCT patients occurred within three days of engraftment and were characterized by diffuse skin rash, fever, weight gain, and hypoalbuminaemia. This peri\u2010engraftment acute GVHD was not observed in MS\u2010HCT or UD\u2010HCT patients. Additionally, a significantly higher proportion of HF\u2010HCT patients achieved complete donor chimaerism in the peripheral mononuclear cells at one month (88%, 46%, and 69% for HF\u2010, MS\u2010 and UD\u2010HCT respectively; <jats:italic>p\u2009=<\/jats:italic>\u20090.001). There was no significant difference in engraftment, chronic GVHD, leukaemia recurrence, non\u2010relapse mortality, and patient survival. In patients with AML in CR who received HCT using ATG\u2010containing conditioning, stronger donor\u2013patient alloreactivity was observed in HF\u2010HCT, in terms of increased acute GVHD and higher likelihood of complete donor chimaerism.<\/jats:p>","DOI":"10.1111\/bjh.18550","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T12:39:46Z","timestamp":1668256786000},"page":"608-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A uniform conditioning regimen of busulfan, fludarabine, and antithymocyte globulin for allogeneic haematopoietic cell transplantation from haploidentical family, matched sibling, or unrelated donors\u2014A single\u2010centre, prospective, explorative study"],"prefix":"10.1111","volume":"200","author":[{"given":"Yunsuk","family":"Choi","sequence":"first","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Ji","family":"Choi","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Seung","family":"Park","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of 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Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Min","family":"Woo","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeran","family":"Kang","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of 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