{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:15:06Z","timestamp":1793697306404,"version":"4.5.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015570","name":"Blood Cancer UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The survival of acute myeloid leukaemia (AML) patients aged over 60 has been suboptimal historically, whether they are treated using hypomethylating agents, low\u2010dose cytarabine (LDAC) or venetoclax\u2010based regimens. Progress is being made, however, for subgroups with favourable molecular or cytogenetic findings. Arginine metabolism plays a key role in AML pathophysiology. We report the only randomised study of LDAC with recombinant arginase BCT\u2010100 versus LDAC alone in older AML patients unsuitable for intensive therapy. Eighty\u2010three patients were randomised to the study. An overall response rate was seen in 19.5% (all complete remission [CR]) and 15% (7.5% each in CR and CR without evidence of adequate count recovery [CRi]) of patients in the LDAC+BCT\u2010100 and LDAC arms respectively (odds ratio 0.73, confidence interval 0.23\u20132.33; <jats:italic>p<\/jats:italic>\u00a0=\u20090.592). No significant difference in overall or median survival between treatment arms was seen. The addition of BCT\u2010100 to LDAC was well tolerated.<\/jats:p>","DOI":"10.1111\/bjh.18560","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T22:44:00Z","timestamp":1669157040000},"page":"573-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A randomised evaluation of low\u2010dose Ara\u2010<scp>C<\/scp> plus pegylated recombinant arginase <scp>BCT<\/scp>\u2010100 versus low dose Ara\u2010<scp>C<\/scp> in older unfit patients with acute myeloid leukaemia: Results from the <scp>LI<\/scp>\u20101 trial"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-0047","authenticated-orcid":false,"given":"Francis","family":"Mussai","sequence":"first","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"De 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