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We analysed patterns of relapses in the H10 trial, validated findings in the RAPID trial and performed a combined analysis stratified by trial. The impact of radiotherapy (RT) on risk of relapse was studied using adjusted Cox models, with time\u2010varying effects. In H10, 1,059 ePETneg patients were included (465 European Organisation for Research and Treatment of Cancer (EORTC) favourable [F], 594 unfavourable [U]). Among the F patients, 2\/227 (1%) relapsed after CMT, 30\/238 (13%) after C: of these relapses, 21\/30 (70%) occurred in less than 2 years and 25\/30 (83%) affected originally involved areas. Among the U group, 16\/292 (5%) relapsed after CMT: 8\/16 (50%) in less than 2 years, 11\/16 (69%) in originally involved areas. After C 30\/302 (10%) relapsed: 27\/30 (90%) in less than 2 years, and 26\/30 (87%) in originally involved areas. Similar results were observed in 419 ePETneg RAPID patients (241\u2009F, 128\u2009U, 50 unclassified): among F patients, 6\/118 (5%) relapsed after CMT; 13\/123 (11%) after C: 11\/13 (85%) in less than 2\u2009years and 11\/13 (85%) affecting originally involved areas. In U patients, 3\/65 (5%) relapsed after CMT and 5\/63 (8%) after C. In both trials, omitting RT in ePETneg HL resulted in more early relapses, mainly affecting originally involved areas. RT significantly reduced risk of early relapses in the combined stratified analysis.<\/jats:p>","DOI":"10.1111\/bjh.18594","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T08:57:36Z","timestamp":1671613056000},"page":"731-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Relapse patterns in early\u2010PET negative, limited\u2010stage Hodgkin lymphoma (HL) after ABVD with or without radiotherapy\u2013a joint analysis of EORTC\/LYSA\/FIL H10 and NCRI RAPID trials"],"prefix":"10.1111","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-6855","authenticated-orcid":false,"given":"Valeria","family":"Fiaccadori","sequence":"first","affiliation":[{"name":"University College London Hospital  London UK"},{"name":"European Organisation for Research and Treatment of Cancer  Brussels Belgium"},{"name":"Cancer Institute University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Neven","sequence":"additional","affiliation":[{"name":"European Organisation for Research and Treatment of Cancer  Brussels Belgium"},{"name":"Luxembourg Institute of Health Competence Center for Methodology and Statistics  Strassen Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fortpied","sequence":"additional","affiliation":[{"name":"European Organisation for Research and Treatment of Cancer  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Aurer","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University Hospital Centre Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Andre","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU UCL Namur  Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Counsell","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre Cancer Institute, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9316-7544","authenticated-orcid":false,"given":"Elizabeth H.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences University of Manchester and Manchester Academic Health Science Centre  Manchester UK"},{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Clifton\u2010Hadley","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre Cancer Institute, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally F.","family":"Barrington","sequence":"additional","affiliation":[{"name":"King's College London and Guy's and St Thomas' PET Centre, School of Biomedical Engineering and Imaging Sciences King's College London, King's Health Partners  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Illidge","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences University of Manchester and Manchester Academic Health Science Centre  Manchester UK"},{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Radford","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences University of Manchester and Manchester Academic Health Science Centre  Manchester UK"},{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M. M.","family":"Raemaekers","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.1194"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25856"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201010\u2010772665"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505949"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620711402414"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.1180"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.103218"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201006\u20102252"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23994"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012643.pub2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(20)30357\u20104"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201001\u2010827246"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)61940\u20105"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00964"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30601\u2010X"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.0699"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.6394"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408648"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2305"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190903040048"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2337177"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T12:30:35Z","timestamp":1692361835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/bjh.18594"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18594","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"2022-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}