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With the introduction of rituximab\u2010 and cytarabine\u2010based immunochemotherapy regimens, the prognosis of the disease has changed dramatically over the last two decades. To assess the real\u2010world survival of patients with MCL, we used a population\u2010based cohort of 564 patients with MCL who were diagnosed and treated between 2000 and 2020. Patient data were collected from seven Finnish treatment centres and one Spanish treatment centre. For the entire patient population, we report a 2\u2010year overall survival (OS) rate of 77%, a 5\u2010year OS of 58%, and a 10\u2010year OS of 32%. The estimated median OS was 80\u2009months after diagnosis. MCL is associated with increased mortality across the entire patient population. Additionally, we assessed the survival of patients after MCL relapse with the aim of establishing a cut\u2010off point of prognostic significance. Based on our statistical analysis of survival after the first relapse, disease progression within 24\u2009months of the initial diagnosis should be considered as a strong indicator of poor prognosis.<\/jats:p>","DOI":"10.1111\/bjh.18597","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T21:29:26Z","timestamp":1670966966000},"page":"64-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Survival of patients with mantle cell lymphoma in the rituximab era: Retrospective binational analysis between 2000 and 2020"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-9985","authenticated-orcid":false,"given":"Minna","family":"Harmanen","sequence":"first","affiliation":[{"name":"Oncology, Faculty of Health Medicine, School of Medicine Institute of Clinical Medicine, University of Eastern Finland  Kuopio 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