{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:38Z","timestamp":1787013938631,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Delayed haemolytic transfusion reaction (DHTR) is a life\u2010threatening haemolytic anaemia following red blood cell transfusion in patients with sickle cell disease, with only scarce data in children. We retrospectively analysed 41 cases of DHTR in children treated between 2006 and 2020 in a French university hospital. DHTR manifested at a median age of 10.5\u2009years, symptoms occurred a median of 8\u2009days after transfusion performed for an acute event (63%), before surgery (20%) or in a chronic transfusion programme (17%). In all, 93% of patients had painful crisis. Profound anaemia (median 49\u2009g\/L), low reticulocyte count (median 140\u2009\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    \/L) and increased lactate dehydrogenase (median 2239\u2009IU\/L) were observed. Antibody screening was positive in 51% of patients, and more frequent when there was a history of alloimmunisation. Although no deaths were reported, significant complications occurred in 51% of patients: acute chest syndrome (12 patients), cholestasis (five patients), stroke (two patients) and kidney failure (two patients). A further transfusion was required in 23 patients and corticosteroids were used in 21 to reduce the risk of additional haemolysis. In all, 13 patients subsequently received further transfusions with recurrence of DHTR in only two. The study affords a better overview of DHTR and highlights the need to establish guidelines for its management in children.\n                  <\/jats:p>","DOI":"10.1111\/bjh.18605","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T09:31:41Z","timestamp":1671615101000},"page":"125-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Delayed haemolytic transfusion reaction in paediatric patients with sickle cell disease: A retrospective study in a French national reference centre"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-8715","authenticated-orcid":false,"given":"Marica","family":"Rossi","sequence":"first","affiliation":[{"name":"Sickle Cell Disease Center, Hematology Unit, Robert Debr\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3547-3994","authenticated-orcid":false,"given":"France","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Etablissement Fran\u00e7ais du Sang, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enora","family":"Le Roux","sequence":"additional","affiliation":[{"name":"CIC 1426, UEC, AP\u2010HP, Nord \u2010 Universit\u00e9 Paris Cit\u00e9, H\u00f4pital Universitaire Robert Debr\u00e9, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamel","family":"Sma\u00efne","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Belloy","sequence":"additional","affiliation":[{"name":"General Pediatrics Unit, Robert Ballanger Hospital  Aulnay\u2010sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9361-4367","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Eyssette\u2010Guerreau","sequence":"additional","affiliation":[{"name":"General Pediatrics Unit, Ren\u00e9 Dubos Hospital  Pontoise France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Couque","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Holvoet","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center, Hematology Unit, Robert Debr\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine","family":"Ithier","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center, Hematology Unit, Robert Debr\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Brousse","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center, Hematology Unit, Robert Debr\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM Unit\u00e9 mixte de recherche (UMR)_S1134  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9reng\u00e8re","family":"Koehl","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center, Hematology Unit, Robert Debr\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM Unit\u00e9 mixte de recherche (UMR)_S1134  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Faye","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"General Pediatrics Unit, Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Benkerrou","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center, Hematology Unit, Robert Debr\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM UMR_S1123  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Missud","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center, Hematology Unit, Robert Debr\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611770"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00059-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-785964"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24908"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13339"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24460"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.038307"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.e661"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.224709"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/307093"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2019.02.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.09.006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001143"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"The International Society of Nephrology","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12950"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00871"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24537"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-327361"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05868.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-807198"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.132738"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008511"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16967"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.104703"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-127176"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-130874"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12217"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T14:03:16Z","timestamp":1692712996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/bjh.18605"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18605","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"2022-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}