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Among a total of 58 HCL cases we studied in these regards, 37 unvaccinated patients, mostly enjoying a relatively long period free from anti\u2010leukaemic treatment, developed COVID\u201019 between March 2020 and December 2021 with a usually favourable outcome (fatality rate: 5\/37, 14%); however, active leukaemia, older age and more comorbidities were associated with a worse course. Postinfection (<jats:italic>n<\/jats:italic>\u00a0=\u200911 cases) and postvaccination (<jats:italic>n<\/jats:italic>\u00a0=\u200928) seroconversion consistently developed, except after recent anti\u2010CD20 or venetoclax therapy, correlating with perivaccine B\u2010cell count. Vaccination appeared to protect from severe COVID\u201019 in 11 patients with breakthrough infection.<\/jats:p>","DOI":"10.1111\/bjh.18606","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T07:59:51Z","timestamp":1671609591000},"page":"411-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["SARS\u2010CoV\u20102 infection and vaccination in patients with hairy\u2010cell leukaemia"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-0931","authenticated-orcid":false,"given":"Enrico","family":"Tiacci","sequence":"first","affiliation":[{"name":"Istituto di Ematologia e Centro di Ricerche Emato\u2010Oncologiche, Dipartimento di Medicina e Chirurgia, Universit\u00e0 e Ospedale di Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-8764","authenticated-orcid":false,"given":"Alessandro","family":"Mancini","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia e Centro di Ricerche Emato\u2010Oncologiche, Dipartimento di Medicina e Chirurgia, Universit\u00e0 e Ospedale di Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7615-0572","authenticated-orcid":false,"given":"Monia","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Ospedaliera Ss Antonio e Biagio e Cesare Arrigo  Alessandria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna Maria","family":"D'Elia","sequence":"additional","affiliation":[{"name":"Ematologia, Ospedale Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Candoni","sequence":"additional","affiliation":[{"name":"Clinica Ematologica, Azienda Sanitaria Universitaria Friuli Centrale\u2010ASUFC  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8407-2903","authenticated-orcid":false,"given":"Alessandro","family":"Morotti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Biologiche, Universit\u00e0 di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-4433","authenticated-orcid":false,"given":"Alessandra","family":"Romano","sequence":"additional","affiliation":[{"name":"Ematologia, Ospedale di Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0769-6891","authenticated-orcid":false,"given":"Alessandro","family":"Gozzetti","sequence":"additional","affiliation":[{"name":"Ematologia, Ospedale di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Broccoli","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Istituto di Ematologia \u201cSer\u00e0gnoli\u201d e Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"De Carolis","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia e Centro di Ricerche Emato\u2010Oncologiche, Dipartimento di Medicina e Chirurgia, Universit\u00e0 e Ospedale di Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bruna","sequence":"additional","affiliation":[{"name":"Ematologia, Ospedale di Novara  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Tisi","sequence":"additional","affiliation":[{"name":"Cell Therapy and Hematology, San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Selleri","sequence":"additional","affiliation":[{"name":"Ematologia, Ospedale di Salerno  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Capponi","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia e Centro di Ricerche Emato\u2010Oncologiche, Dipartimento di Medicina e Chirurgia, Universit\u00e0 e Ospedale di Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Vallisa","sequence":"additional","affiliation":[{"name":"Ematologia, Ospedale di Piacenza  Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Ematologia, ASST\u2010Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo Giovanni","family":"Della Porta","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Clinical and Research Center &amp; 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