{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:27:26Z","timestamp":1782844046139,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["413490537"],"award-info":[{"award-number":["413490537"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We retrospectively analysed all German inpatient cases of haemophagocytic lymphohistiocytosis (HLH) from 2014 to 2020 to describe the epidemiology, clinical course, and underlying diseases of 4065 HLH patients. The age\u2010standardized incidence rate of HLH in Germany was 0.52\/100\u2009000 people in 2014 and steadily increased by 10% per year to 0.97\/100\u2009000 in 2020 (mean 0.70\/100\u2009000). Inpatient deaths related to HLH increased from 0.84\/1\u2009000\u2009000 people in 2014 to 2.32\/1\u00a0000\u2009000 people in 2020, caused by rising numbers of older HLH patients. Overall, HLH is more frequent than previously expected and incidence as well as HLH\u2010related deaths increased significantly.<\/jats:p>","DOI":"10.1111\/bjh.18617","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:03:38Z","timestamp":1671494618000},"page":"285-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Epidemiology of haemophagocytic lymphohistiocytosis at the population level in Germany"],"prefix":"10.1111","volume":"201","author":[{"given":"David","family":"Kuron","sequence":"first","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology University Hospital Schleswig\u2010Holstein, Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Christoph","family":"Voran","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Cardiology University Hospital Schleswig\u2010Holstein, Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich Alexander","family":"von Samson\u2010Himmelstjerna","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital Schleswig\u2010Holstein, Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Baldus","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology University Hospital Schleswig\u2010Holstein, Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kunzendorf","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital Schleswig\u2010Holstein, Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schulte","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital Schleswig\u2010Holstein, Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6331-8388","authenticated-orcid":false,"given":"Benedikt","family":"Kolbrink","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital Schleswig\u2010Holstein, Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61048-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001048"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-020-03139-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-020-01031-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1991.tb11878.x"},{"key":"e_1_2_12_8_1","unstructured":"Statistisches Bundesamt Deutschland \u2010 GENESIS\u2010Online [Internet].2022[cited 2022 Jun 14]. 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