{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:43:32Z","timestamp":1784673812775,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Autoimmune haemolytic anaemia (AIHA) and immune thrombocytopenia (ITP) are two uncommon haematologic autoimmune conditions that can rarely arise secondary to vaccination. Prior studies using the US Centers for Disease Control's (CDC) Vaccine Adverse Event Reporting System (VAERS) have demonstrated this infrequency, but contemporary data as well as comparison with current information regarding SARS\u2010CoV\u20102 vaccination has not been assessed. In this study, we reviewed VAERS database reports from 1990 to 2022 to characterize the incidence and clinical and laboratory findings of non\u2010SARS\u2010CoV\u20102\u2010associated AIHA and ITP and SARS\u2010CoV\u20102 vaccine\u2010associated AIHA and ITP. We discovered a total of 863 AIHA and ITP reports following vaccination with 15 non\u2010SARS\u2010CoV\u20102 and four SARS\u2010CoV\u20102 vaccines submitted to the CDC VAERS database. AIHA and ITP reporting was low for both groups, with a large proportion excluded due to a lack of clinical details. ITP was reported the most frequently in both groups and was significantly more common with measles\u2013mumps\u2013rubella (MMR) vaccination (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in the non\u2010SARS\u2010CoV\u20102 group. AIHA and ITP cases were higher in the SARS\u2010CoV\u20102 vaccine group, though ultimately still very infrequent. Autoimmune haematologic disease is vanishingly rare after immunization and rates are lower than in the general population according to passive reporting.<\/jats:p>","DOI":"10.1111\/bjh.18627","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:48:13Z","timestamp":1671842893000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Autoimmune haemolytic anaemia and immune thrombocytopenia following <scp>SARS\u2010CoV<\/scp>\u20102 and <scp>non\u2010SARS\u2010CoV<\/scp>\u20102 vaccination: 32\u2009Years of passive surveillance data"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-9685","authenticated-orcid":false,"given":"Jeremy W.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-9480","authenticated-orcid":false,"given":"Garrett S.","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Guarente","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anatomy, and Cell Biology Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-7841","authenticated-orcid":false,"given":"Danielle","family":"Schlafer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services, Emory Healthcare  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-2762","authenticated-orcid":false,"given":"Brian D.","family":"Adkins","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine and Hemostasis, Department of Pathology University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.114561"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-754119"},{"key":"e_1_2_11_4_1","unstructured":"US FDA.FDA Approves First COVID\u201019 Vaccine [Internet].2021Aug 23. 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