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This retrospective, multicenter study included 162 patients who received ASCT for relapsed FL in Alberta, Canada. With a median (range) follow\u2010up time of 12.5\u2009years (0.1\u201327.9), the 12\u2010year time\u2010to\u2010progression (TTP) was 57% (95% confidence interval [CI] 49%\u201365%), time\u2010to\u2010next\u2010treatment was 61% (95% CI 52%\u201369%), progression\u2010free survival was 51% (95% CI 42%\u201359%) and overall survival was 69% (95% CI 60%\u201376%). A plateau emerged on the TTP curve at 57% starting 9\u2009years after ASCT with no relapses occurring beyond this timepoint. Ten patients remained in remission 20\u2009years or more after ASCT. Patients undergoing ASCT at first or second relapse had superior outcomes compared to third or later relapse (12\u2010year TTP 61% vs. 34%), as did patients without progression of disease within 24\u2009months (POD24) of frontline treatment versus those with POD24 (12\u2010year TTP 67% vs. 50%). ASCT achieves high rates of durable remission in relapsed FL, with long\u2010term follow\u2010up revealing that more than 50% of transplanted patients may be functionally cured of their lymphoma. The optimal timing to consider ASCT is at first or second relapse, regardless of POD24 status.<\/jats:p>","DOI":"10.1111\/bjh.18640","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T03:54:17Z","timestamp":1673322857000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term follow\u2010up demonstrates curative potential of autologous stem cell transplantation for relapsed follicular lymphoma"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8918-6598","authenticated-orcid":false,"given":"Robert","family":"Puckrin","sequence":"first","affiliation":[{"name":"Tom Baker Cancer Centre and University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Chua","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute and University of Alberta  Edmonton 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