{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:18:53Z","timestamp":1789600733998,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with immune thrombocytopenic purpura (ITP) often receive corticosteroids as a first\u2010line treatment strategy. The ability to predict the therapeutic response to corticosteroids before initiating treatment would reduce the risk of adverse events, but biomarkers of this parameter have not yet been established. Here, in a single\u2010centre, retrospective, cohort study of 127 ITP patients who received corticosteroids as first\u2010line treatment, we compared several characteristics and test results between those patients with a favourable response to corticosteroids (responder cohort, <jats:italic>n<\/jats:italic>\u00a0=\u200968) and those with a poor response to corticosteroids (non\u2010responder cohort, <jats:italic>n<\/jats:italic>\u00a0=\u200959) to identify potential biomarkers that were predictive of corticosteroid response. We extracted six factors as indicative of poor response to corticosteroid therapy for ITP: old age (\u226581\u2009years) (odds ratio [OR], 2.44; <jats:italic>p<\/jats:italic>\u00a0=\u20090.02); low platelet count (&lt;9\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) (OR, 2.25; <jats:italic>p<\/jats:italic>\u00a0=\u20090.02); high level of platelet\u2010associated IgG (\u2265445\u2009ng\/10<jats:sup>7<\/jats:sup>cells) (OR, 3.95; <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01), high platelet distribution width (\u2265\u200914.0\u00a0g\/dL) (OR, 2.00; <jats:italic>p<\/jats:italic>\u00a0=\u20090.03), high lymphocyte\u2010to\u2010monocyte ratio (\u2265\u20093.52) (OR, 1.40, <jats:italic>p<\/jats:italic>\u00a0=\u20090.04), and low megakaryocyte count in bone marrow (&lt;\u200985.5\/\u03bcl) (OR, 1.72; <jats:italic>p<\/jats:italic>\u00a0=\u20090.04). Thus, our present data support the fact that these six factors are useful biomarkers for predicting corticosteroid response in patients with ITP.<\/jats:p>","DOI":"10.1111\/bjh.18670","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T12:07:39Z","timestamp":1674907659000},"page":"774-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomarkers for predicting response to corticosteroid therapy for immune thrombocytopenic purpura"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-1952","authenticated-orcid":false,"given":"Naokazu","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Hematology Shinko Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Tsunemine","sequence":"additional","affiliation":[{"name":"Department of Hematology Shinko Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Hematology Shinko Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Hematology Shinko Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010501"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/RAW2-0LQW-8YTX-941V"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb06281.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-019-02790-z"},{"issue":"4","key":"e_1_2_9_10_1","first-page":"477","article-title":"Adverse effects of corticosteroids","volume":"23","author":"Goette 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