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Basic standard of care therapy includes regular transfusions to maintain a haemoglobin level of around 10 g\/dL, together with iron chelation therapy to prevent iron overload. Novel therapies, bone marrow transplantation, and gene therapy are treatment options that are unavailable in many countries with stressed economies. This Wider Perspectives article presents the strategies for management of an adolescent refugee patient with beta thalassaemia, as it would be performed by expert haematologists in six countries: Italy, Lebanon, Oman, the Sudan, Thailand and the United States. The experienced clinicians in each country have adapted their practice according to the resources available, which vary greatly. Even in the current modern era, providing adequate transfusions and chelation is problematic in many countries. On the other hand, ensuring adherence to therapy, particularly during adolescence, is a similar challenge seen in all countries. The concluding section highlights the disparities in available therapies and puts the role of novel therapies into a societal context.<\/jats:p>","DOI":"10.1111\/bjh.18671","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T12:44:33Z","timestamp":1676637873000},"page":"199-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Thalassaemia\u2014A global view"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-9756","authenticated-orcid":false,"given":"Peter","family":"Hokland","sequence":"first","affiliation":[{"name":"Faculty of Health, Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-0052","authenticated-orcid":false,"given":"Shahina","family":"Daar","sequence":"additional","affiliation":[{"name":"College of Medicine &amp; Health Sciences Sultan Qaboos University  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-5630","authenticated-orcid":false,"given":"Wael","family":"Khair","sequence":"additional","affiliation":[{"name":"Khartoum Oncology Hospital  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-1244","authenticated-orcid":false,"given":"Sujit","family":"Sheth","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Department of Pediatrics Weill Cornell Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-2238","authenticated-orcid":false,"given":"Ali T.","family":"Taher","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Internal Medicine American University of Beirut Medical Centre  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-5570","authenticated-orcid":false,"given":"Lorenza","family":"Torti","sequence":"additional","affiliation":[{"name":"Hemoglobinopathies Unit, Hematology Department S. 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