{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:10:49Z","timestamp":1791508249220,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This cross\u2010sectional study aimed to develop and validate a patient\u2010reported outcomes (PROs) assessment tool to assess symptom burden and daily functioning in patients after chimeric antigen receptor (CAR) T\u2010cell therapy, the MD Anderson Symptom Inventory (MDASI\u2010CAR). The items were generated based on literature review, content elicitation interviews with patients, and clinician's review. The patients completed the MDASI core and module, single\u2010item quality\u2010of\u2010life (QoL) measure and Patient\u2010Reported Outcomes Measurement Information System\u201029 (PROMIS\u201029). The psychometric validation analysis was based on the acceptability after item reduction process. The final 10 MDASI\u2010CAR module items included tremors, fever\/chills, headache, balance, dizziness, attention, difficulty speaking, coughing, sexual dysfunction, and diarrhoea with high internal consistency (Cronbach's alpha: MDASI Core, 0.865; MDASI Interference, 0.915; CAR\u2010T module, 0.746). The MDASI\u2010CAR has excellent known\u2010group validity that was demonstrated by differentiate patients based on patient's performance status (Cohen's <jats:italic>d<\/jats:italic> for MDASI core\u00a0=\u00a0\u22121.008, interference\u00a0=\u00a0\u22120.771, module\u00a0=\u00a0\u22120.835). Criterion validity was demonstrated by the significant correlations between the MDASI\u2010CAR composite score, the single QoL item and the relevant domains on PROMIS\u201029 (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). This study established the MDASI\u2010CAR module as a reliable and valid PRO tool for monitoring symptom burden after CAR T\u2010cell therapy in patients with haematological malignancies. The findings need to be validated with a longitudinal design.<\/jats:p>","DOI":"10.1111\/bjh.18677","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T06:55:12Z","timestamp":1675407312000},"page":"738-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Development and validation of a patient\u2010reported outcome measure to assess symptom burden after chimeric antigen receptor T\u2010cell therapy"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-8005","authenticated-orcid":false,"given":"Xin Shelley","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-2025","authenticated-orcid":false,"given":"Samer 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Integrative Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010En","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Cleeland","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University 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