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The Fondazione Italiana Linfomi has recently published a multicentre prospective observational study, the \u2018Elderly Project\u2019, on the outcome of DLBCL in patients aged \u226565\u2009years, evaluated using a simplified comprehensive geriatric assessment. The aim of this study was to compare biological and clinical features of HCV positive (HCV+) with HCV negative (HCV\u2212) cases. A total of 89 HCV+ patients were identified out of 1095 evaluated for HCV serology (8.1%). The HCV+ patients were older, less fit, and had frequent extranodal involvement. The cell\u2010of\u2010origin determination by Nanostring showed that HCV+ cases less frequently had an activated B\u2010cell profile compared to HCV\u2212 patients (18% vs. 43%). In all, 86% of HCV+ patients received rituximab\u2010cyclophosphamide, doxorubicin, vincristine (Oncovin) and prednisone (R\u2010CHOP)\u2010like immunochemotherapy. Grade 3\u20134 liver toxicity occurred in 3% of cases. Among centrally reviewed cases confirmed as DLBCL, the 3\u2010year overall survival of HCV+ patients was very similar to HCV\u2212 (63% vs. 61%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.926). In all, 20 HCV+ patients were treated with direct\u2010acting antiviral agents (DAAs), with good tolerance and sustained virological response in all cases. The 3\u2010year progression\u2010free survival for this subgroup was excellent (77%), suggesting DAAs' possible role in reducing the risk of relapse by eliminating the viral trigger.<\/jats:p>","DOI":"10.1111\/bjh.18678","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T06:18:48Z","timestamp":1675405128000},"page":"653-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biological features and outcome of diffuse large B\u2010cell lymphoma associated with hepatitis C virus in elderly patients: Results of the prospective \u2018Elderly Project\u2019 by the Fondazione Italiana Linfomi"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-5947","authenticated-orcid":false,"given":"Annalisa","family":"Arcari","sequence":"first","affiliation":[{"name":"Hematology Unit Ospedale Guglielmo da Saliceto  Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-2248","authenticated-orcid":false,"given":"Valentina","family":"Tabanelli","sequence":"additional","affiliation":[{"name":"Division of Haematopathology European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Merli","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Unit\u00e0 Sanitaria Locale\u2010IRCCS  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Fondazione Italiana Linfomi\u2014Onlus  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-5927","authenticated-orcid":false,"given":"Michele","family":"Merli","sequence":"additional","affiliation":[{"name":"Division of Hematology, Ospedale di Circolo and Fondazione Macchi University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Balzarotti","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio Ruggero","family":"Zilioli","sequence":"additional","affiliation":[{"name":"Division of Hematology ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Unit of Hematology Azienda Ospedaliera Universitaria Senese  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Molecular Biotechnologies and Health Sciences University of Torino\/AOU Citt\u00e0 della Salute e della Scienza di Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Margiotta","family":"Casaluci","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Translational Medicine University of Eastern Piedmont  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Tucci","sequence":"additional","affiliation":[{"name":"Department of Hematology ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Puccini","sequence":"additional","affiliation":[{"name":"Hematology Department University of Florence and AOU Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Pennese","sequence":"additional","affiliation":[{"name":"Lymphoma Unit, Department of Hematology Ospedale Spirito Santo  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Di\u00a0Rocco","sequence":"additional","affiliation":[{"name":"Department of Traslational and Precision Medicine Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Zanni","sequence":"additional","affiliation":[{"name":"Division of Hematology A.O. 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