{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:40:39Z","timestamp":1788237639439,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Clinical data on primary central nervous system (CNS) lymphoma (PCNSL) patients is mostly generated from prospective studies, and many frail real\u2010world patients are not included. Recently,the diagnosis and treatment of PCNSL patients was confounded by the COVID\u201019 pandemic. In particular, treatment with high\u2010dose cytarabine was linked to increased risk of pneumonia and virus persistence. We report on outcome of the induction regimen R\u2010MIV (rituximab, methotrexate, ifosfamide, and vincristine) involving intensive administration of high\u2010dose methotrexate (3.5\u00a0g\/m<jats:sup>2<\/jats:sup>) with ifosfamide, every 2\u2009weeks and rituximab once per week for six doses. The median age and performance status (PS) for 64 patients was 58\u2009years and 2 (PS 3; 22%) respectively. The overall response rate by magnetic resonance imaging\/computed tomography (MRI\/CT) was 73% (<jats:italic>n<\/jats:italic>\u00a0=\u00a046\/63), with an additional 17.5% (<jats:italic>n<\/jats:italic>\u00a0=\u00a011\/63) patients without measurable disease at baseline. Grade 3\u20134 haematological toxicity was low for R\u2010MIV (neutropenia: 25% and thrombocytopenia: 1%). Three patients (4.7%) died from treatment\u2010related toxicity. Co\u2010existence of SARS\u2010CoV\u20102 infection with cytomegalovirus reactivation and the varicella\u2010zoster virus in two patients was fatal. Fifty patients (78%) were eligible for consolidation. Median progression\u2010free and overall survival were not reached (median follow\u2010up: 44\u2009months). In conclusion, the R\u2010MIV regimen is feasible in routine practice, effective and safe, even during the COVID\u201019 pandemic.<\/jats:p>","DOI":"10.1111\/bjh.18687","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T11:53:13Z","timestamp":1676029993000},"page":"663-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety and efficacy of induction immunochemotherapy with rituximab, methotrexate, ifosfamide, and vincristine (<scp>R\u2010MIV<\/scp>) in patients with primary <scp>CNS<\/scp> lymphoma including recent <scp>COVID<\/scp>\u201019 pandemic experience"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-1031","authenticated-orcid":false,"given":"Beata","family":"Ostrowska","sequence":"first","affiliation":[{"name":"Department of Lymphoid Malignancies Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw 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