{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:39:37Z","timestamp":1778236777484,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Extranodal NK\/T\u2010cell lymphoma, nasal type is a rare and aggressive form of lymphoma, historically associated with poor prognosis. We report here the results of a retrospective multi\u2010centre study evaluating the efficacy of MGAD (methotrexate, gemcitabine, L\u2010asparaginase and dexamethasone) regimen (two cycles) combined with \u2018sandwich\u2019 radiotherapy in 35 patients with localised newly diagnosed extranodal NK\/T\u2010cell lymphoma. Thirty\u2010two patients (91%) reached complete remission. With a long median follow\u2010up of 59.6\u00a0months, progression\u2010free and overall survival at 2 and 5\u2009years were 71%, 80% and 53%, 73%, respectively. Around one third of the patients experienced relapse within a median time of 14.5\u00a0months. Side\u2010effects were manageable with grades 3\u20134 cytopenias, mucositis and infection in 50%, 24% and 21% of the cases, respectively. Monitoring of asparaginase activity was performed in 13 patients and showed inactivation of the drug in seven (54%) patients. Our results indicate that a short therapy by sandwich MGAD chemoradiotherapy is a tolerable and effective treatment option in localised newly diagnosed extranodal NK\/T\u2010cell lymphoma patients.<\/jats:p>","DOI":"10.1111\/bjh.18689","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T13:04:54Z","timestamp":1676639094000},"page":"673-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of a short sandwich protocol, methotrexate, gemcitabine, L\u2010asparaginase and dexamethasone chemotherapy combined with radiotherapy, in localised newly diagnosed <scp>NK<\/scp>\/T\u2010cell lymphoma: A French retrospective study"],"prefix":"10.1111","volume":"201","author":[{"given":"Sammara","family":"Chaubard","sequence":"first","affiliation":[{"name":"Hematology Department Limoges University Hospital  Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Marouf","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, INSERM U1163, Imagine Institute Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lavergne","sequence":"additional","affiliation":[{"name":"Hematology Department Limoges University Hospital  Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Lemonnier","sequence":"additional","affiliation":[{"name":"Hematology Department, Henri Mondor University Hospital, Assistance Publique des H\u00f4pitaux de Paris, INSERM U955, Mondor Institute for Biomedical Research Paris\u2010Est Cr\u00e9teil University  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Hematology Department Necker Hospital, Assistance Publique des H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Clavert","sequence":"additional","affiliation":[{"name":"Hematology Department Angers University Hospital  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9my","family":"Gressin","sequence":"additional","affiliation":[{"name":"Hematology Department Grenoble University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Cartron","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital Center UMR\u2010CNRS 5235  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"Waultier\u2010Rascalou","sequence":"additional","affiliation":[{"name":"Hematology Department N\u00eemes University Hospital  N\u00eemes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Vargaftig","sequence":"additional","affiliation":[{"name":"Hematology Department Ren\u00e9 Huguenin Hospital\u2010Curie Institute  Saint\u2010Cloud France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Salles","sequence":"additional","affiliation":[{"name":"Hematology Department Lyon\u2010Sud Hospital, University of Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Bachy","sequence":"additional","affiliation":[{"name":"Hematology Department Lyon\u2010Sud Hospital, University of Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-3718","authenticated-orcid":false,"given":"Herv\u00e9","family":"Ghesqui\u00e8res","sequence":"additional","affiliation":[{"name":"Hematology Department Lyon\u2010Sud Hospital, University of Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-621X","authenticated-orcid":false,"given":"Olivier","family":"Tournilhac","sequence":"additional","affiliation":[{"name":"Hematology Department Clermont University Hospital of Clermont\u2010Ferrand, Clermont Auvergne University  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrien","family":"Chauchet","sequence":"additional","affiliation":[{"name":"Hematology Department Jean Minjoz University Hospital  Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Le\u00a0Gouill","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique H\u00f4tel\u2010Dieu, CHU Nantes, INSERM, CNRS, CRCINA Nantes, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gandhi","family":"Damaj","sequence":"additional","affiliation":[{"name":"Hematology Institute Caen University Hospital, Normandy University  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1866-971X","authenticated-orcid":false,"given":"Luc\u2010Matthieu","family":"Fornecker","sequence":"additional","affiliation":[{"name":"Hematology Department Strasbourg University Hospital  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-625X","authenticated-orcid":false,"given":"David","family":"Sibon","sequence":"additional","affiliation":[{"name":"Hematology Department Necker Hospital, Assistance Publique des H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0039-1983","authenticated-orcid":false,"given":"Lucie","family":"Ob\u00e9ric","sequence":"additional","affiliation":[{"name":"Hematology Department Toulouse\u2010Oncopole University Cancer Institute (IUCT\u2010O)  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-3331","authenticated-orcid":false,"given":"Jean\u2010Marie","family":"Michot","sequence":"additional","affiliation":[{"name":"Gustave Roussy Institute, D\u00e9partement des Innovations Th\u00e9rapeutiques et Essais Pr\u00e9coces Universit\u00e9 Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gaulard","sequence":"additional","affiliation":[{"name":"Pathology Department, Henri Mondor University Hospital, Assistance Publique des H\u00f4pitaux de Paris, INSERM U955, Mondor Institute for Biomedical Research Paris\u2010Est Cr\u00e9teil University  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, INSERM U1163, Imagine Institute Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Hematology Department Necker Hospital, Assistance Publique des H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-5482","authenticated-orcid":false,"given":"Lucile","family":"Couronn\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, INSERM U1163, Imagine Institute Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Onco\u2010Hematology Necker Children's Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Jaccard","sequence":"additional","affiliation":[{"name":"Hematology Department Limoges University Hospital  Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01313-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01293-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11102699"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402148"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.2573"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21256"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0669-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-307454"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.907894"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8647"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.8295"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2395-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2244-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12405"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.24310"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx684"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1755"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-012-9889-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2136-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2016.1264163"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S179567"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.2083"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00533-1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11319"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26629"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.10.011"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16334"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.569"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2137-6"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3327"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.1384"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4505"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1961058"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1563690"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245951"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1386305"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-117165"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-118439"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.051"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.03.014"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.766200"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.18689","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:58:11Z","timestamp":1718697491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/bjh.18689"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18689","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]},"assertion":[{"value":"2022-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}