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Using clinical trial data and relative survival approaches, we estimated the 10\u2010year net survival (NS) and we described the excess mortality hazard (EMH) due (directly or indirectly) to the DLBCL, over time and according to main prognosis factors using flexible regression modelling. The 10\u2010year NS was 65% [59; 71]. Using the flexible modelling, we showed that the EMH decreases steeply after diagnosis. The variables \u2018performance status\u2019, \u2018number of extra\u2010nodal sites\u2019 and the serum \u2018lactate dehydrogenase\u2019 were strongly associated with the EMH, even after adjustment on other important variables. EMH is very close to zero at 10\u2009years for the whole population, so DLBCL patients do not experience an increased mortality compared to the general population in the long term. The number of extra\u2010nodal sites was an important prognostic factor shortly after diagnosis, suggesting that it is correlated with an important but unmeasured prognostic factor that would lead to this selection effect over time.<\/jats:p>","DOI":"10.1111\/bjh.18705","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T02:35:05Z","timestamp":1677119705000},"page":"857-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term excess mortality and net survival among elderly diffuse large B\u2010cell lymphoma patients after front\u2010line <scp>R\u2010CHOP<\/scp> treatment"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1410-5172","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Belot","sequence":"first","affiliation":[{"name":"Biostatistics Department LYSARC, H\u00f4pital Lyon\u2010Sud  Pierre\u2010B\u00e9nite 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