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Two clinical and four biochemical TLS occurred (4.1%). Five of the six events occurred in high\u2010risk patients, four occurred at 20\u2009mg dose and three at the 6\u2010h time\u2010point. Inpatient versus outpatient TLS rates within the high\u2010risk subgroup were 15% and 8%. Risk category was the only predictor of TLS events in multivariate analysis. Outpatient escalation did not associate with clinically meaningful TLS events, suggesting outpatient escalation has manageable associated TLS risks, including in high\u2010risk cohorts. These observations require confirmation in larger studies.<\/jats:p>","DOI":"10.1111\/bjh.18738","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T11:15:02Z","timestamp":1679570102000},"page":"48-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Venetoclax ramp\u2010up strategies for <scp>chronic lymphocytic leukaemia<\/scp> in the <scp>United Kingdom<\/scp>: a real world multicentre retrospective study"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2773-4982","authenticated-orcid":false,"given":"Rocio","family":"Figueroa\u2010Mora","sequence":"first","affiliation":[{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Rampotas","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Halperin","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Worth","sequence":"additional","affiliation":[{"name":"Milton Keynes University Hospital NHS Foundation Trust  Milton Keynes UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Vidler","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Melotti","sequence":"additional","affiliation":[{"name":"University College of London Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ferguson","sequence":"additional","affiliation":[{"name":"University Hospitals of North Midland NHS Trust  Stoke\u2010on\u2010Trent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagah","family":"Elmusharaf","sequence":"additional","affiliation":[{"name":"Cardiff and Vale University Health Board  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Preston","sequence":"additional","affiliation":[{"name":"University of Aberdeen  Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Furtado","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospitals NHS Trust  Cornwall UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Dungarwalla","sequence":"additional","affiliation":[{"name":"Milton Keynes University Hospital NHS Foundation Trust  Milton Keynes UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyen","family":"Gohill","sequence":"additional","affiliation":[{"name":"University College of London Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piers","family":"Patten","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Kennedy","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6631-9749","authenticated-orcid":false,"given":"Toby A.","family":"Eyre","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schuh","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Fox","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-0769","authenticated-orcid":false,"given":"Tahla","family":"Munir","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Martinez\u2010Calle","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"Venclyxto (venetoclax) summary of product characteristics (SpC). 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