{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:47:13Z","timestamp":1747183633883,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013229","name":"C17 Children's Cancer and Blood Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000163","name":"Pediatric Oncology Group of Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000163","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We leveraged population\u2010based clinical and healthcare data to identify treatment patterns and long\u2010term outcomes among adolescents and young adults (AYA) with nodular lymphocyte\u2010predominant Hodgkin lymphoma (NLPHL). All Ontario, Canada, AYA aged 15\u201321\u2009years at diagnosis with NLPHL between 1992 and 2012 were identified, and their detailed clinical data were collected. Linkage to healthcare databases identified additional events (subsequent malignant neoplasms [SMN], relapses and deaths). Event\u2010free survival (EFS) and overall survival (OS) were compared by locus of care (adult vs. paediatric) and predictors of outcomes determined. Of 1014 AYA with Hodgkin lymphoma, 54 (5.3%) had NLPHL; 15 (27.8%) were treated at a paediatric centre. No paediatric centre patient received radiation only versus 16 (41.0%) of adult centre patients. Excision only was more common in paediatric centres (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The 20\u2010year EFS and OS rates were 82.9%\u2009\u00b1\u20095.2% and 100% respectively. Advanced stage (hazard ratio: 4.9, 95% CI: 1.3\u201318.4; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) was associated with inferior EFS. Although the 25\u2010year cumulative incidence of SMN was 19.3%\u2009\u00b1\u20099.6% for the entire cohort, there were no SMN among the patients treated with excision only. AYA with NLPHL have outstanding long\u2010term survival. Resection alone was rare outside of paediatric institutions but associated with excellent outcomes. Given substantial SMN risks, chemotherapy\u2010sparing and radiation\u2010sparing strategies for appropriate subsets of patients are warranted.<\/jats:p>","DOI":"10.1111\/bjh.18757","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T01:54:01Z","timestamp":1680659641000},"page":"1081-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment patterns and outcomes in adolescents and young adults with nodular lymphocyte\u2010predominant Hodgkin lymphoma: an <scp>IMPACT<\/scp> cohort study"],"prefix":"10.1111","volume":"201","author":[{"given":"Angela","family":"Punnett","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy N.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Institute for Health Policy, Evaluation and Management University of Toronto  Toronto Ontario Canada"},{"name":"Cancer Research Program, ICES  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Surgery and Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Melbourne School of Population and Global Health University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-4582","authenticated-orcid":false,"given":"David","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto  Toronto Ontario Canada"},{"name":"Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Pediatric Oncology Group of Ontario  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinku","family":"Sutradhar","sequence":"additional","affiliation":[{"name":"Institute for Health Policy, Evaluation and Management University of Toronto  Toronto Ontario Canada"},{"name":"Cancer Research Program, ICES  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Pole","sequence":"additional","affiliation":[{"name":"Cancer Research Program, ICES  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Health Services Research The University of Queensland  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Lau","sequence":"additional","affiliation":[{"name":"Cancer Research Program, ICES  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto  Toronto Ontario Canada"},{"name":"Cancer Research Program, ICES  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-3670","authenticated-orcid":false,"given":"Sumit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto  Toronto Ontario Canada"},{"name":"Cancer Research Program, ICES  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201001\u2010643569"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8869"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27375"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201010\u2010877761"},{"key":"e_1_2_9_7_1","unstructured":"NCCN.Clinical Practice Guidelines in Oncology for Pediatric Hodgkin Lymphoma Version 1.2022. 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