{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:22:20Z","timestamp":1787066540942,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>B\u2010cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B\u2010cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down\u2010regulation of CD73 in HL with low B cells suggestive of an antibody\u2010independent function of B cells in the TME of HL.<\/jats:p>","DOI":"10.1111\/bjh.18762","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T19:23:23Z","timestamp":1678908203000},"page":"1097-1102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Low B\u2010cell content is associated with a\n                    <scp>CD73<\/scp>\n                    \u2010low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma"],"prefix":"10.1111","volume":"201","author":[{"given":"Johanna","family":"Grund","sequence":"first","affiliation":[{"name":"Hematopathology Section and Lymph Node Registry, Department of Pathology University Hospital Schleswig\u2010Holstein  Kiel 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General, Visceral, Cancer and Transplantation Surgery; Faculty of Medicine and University Hospital of Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Schl\u00f6\u00dfer","sequence":"additional","affiliation":[{"name":"Center of Molecular Medicine, Cologne Translational Immunology University of Cologne  Cologne Germany"},{"name":"Department of General, Visceral, Cancer and Transplantation Surgery; Faculty of Medicine and University Hospital of Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"von Tresckow","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD), Faculty of Medicine and University Hospital of Cologne University of Cologne  Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG)  Cologne 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