{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:50:29Z","timestamp":1788403829607,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pre\u2010transplant measurable residual disease (MRD) predicts relapse and outcome of allogeneic haematopoietic cell transplantation (allo\u2010HCT). The impact of MRD on the outcomes of post\u2010transplant cyclophosphamide (PTCy)\u2010based allo\u2010HCT from a matched unrelated donor (UD) is unknown. This study assessed the impact of MRD in acute myeloid leukaemia (AML) in the first complete remission (CR1). A total of 272 patients (MRD negative [MRD\u2212], <jats:italic>n<\/jats:italic>\u00a0=\u2009165; MRD positive [MRD+], <jats:italic>n<\/jats:italic>\u00a0=\u2009107) with a median follow\u2010up of 19 (range: 16\u201324) months were studied. The incidence of grades II\u2013IV and grades III\u2013IV acute GVHD at day 180 was 25.2% and 25% (<jats:italic>p<\/jats:italic>\u00a0=\u20090.99), and 10.6% and 6.8% (<jats:italic>p<\/jats:italic>\u00a0=\u20090.29), respectively, and 2\u2010year chronic GVHD was 35% and 30.4% (<jats:italic>p<\/jats:italic>\u00a0=\u20090.96) in MRD+ and MRD\u2212 cohorts, respectively. In multivariate analysis, MRD+ status was associated with a higher incidence of relapse (RI) (hazard ratio [HR]\u00a0=\u00a02.56, 95% CI: 1.39\u20134.72), lower leukaemia\u2010free survival (LFS) (HR\u00a0=\u00a02.04, 95% CI: 1.23\u20133.39), overall survival (OS) (HR\u00a0=\u00a01.83, 95% CI: 1.04\u20133.25) and GVHD\u2010free, relapse\u2010free survival (GRFS) (HR\u00a0=\u00a01.69, 95% CI: 1.10\u20132.58). MRD status did not have a significant impact on non\u2010relapse mortality (NRM), or acute or chronic GVHD risk. Among patients with AML undergoing UD allo\u2010HCT with PTCy, pre\u2010transplant MRD+ status predicted a higher relapse rate, lower LFS, OS and GRFS.<\/jats:p>","DOI":"10.1111\/bjh.18765","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T05:37:13Z","timestamp":1679549833000},"page":"1169-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of measurable residual disease on outcomes of unrelated donor haematopoietic cell transplantation with post\u2010transplant cyclophosphamide in AML in first complete remission"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-1265","authenticated-orcid":false,"given":"Arnon","family":"Nagler","sequence":"first","affiliation":[{"name":"Division of Hematology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"INSERM UMRs 938, Sevice d'h\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, H\u00f4pital Saint\u2010Antoine Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2371-3655","authenticated-orcid":false,"given":"Bhagirathbhai","family":"Dholaria","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Department of Hematology Institut Paoli Calmettes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"Raisa Gorbacheva Memorial Research Institute for Paediatric Oncology, Hematology First State Pavlov Medical University of St Petersburg  St Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vydra","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Institute of Hematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goda","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rovira","sequence":"additional","affiliation":[{"name":"Hematology Hospital Clinic, Institute of Hematology &amp; Oncology  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Rem\u00e9nyi","sequence":"additional","affiliation":[{"name":"Haematology and Stem Cell Transplant D\u00e9l\u2010pesti Centrumk\u00f3rh\u00e1z\u2013Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude Eric","family":"Bulabois","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie CHU Grenoble Alpes 38043  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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