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In this study, we describe 105 consecutive ACS episodes in 81 adult patients during a 32\u2010month period and compare the characteristics as a function of the time to onset after hospital admission for a vaso\u2010occlusive crisis (VOC), that is early\u2010onset episodes (time to onset \u226424\u2009h, 42%) versus secondary episodes (&gt;24\u2009h, 58%; median [interquartile range] time to onset: 2 [2\u20133] days). The median age was 27 [22\u201334] years, 89% of the patients had an S\/S or S\/\u03b2<jats:sup>0<\/jats:sup>\u2010thalassaemia genotype; 81% of the patients had a history of ACS (median: 3 [2\u20135] per patient), only 61% were taking a disease\u2010modifying treatment at the time of the ACS. Fever and chest pain were noted in respectively 54% and 73% of the episodes. Crackles (64%) and bronchial breathing (32%) were the main abnormal auscultatory findings. A positive microbiological test was found for 20% of episodes. Fifty percent of the episodes required a blood transfusion; ICU transfer and mortality rates were respectively 29% and 1%. Secondary and early\u2010onset forms of ACS did not differ significantly. Disease\u2010modifying treatments should be revaluated after each ACS episode because the recurrence rate is high.<\/jats:p>","DOI":"10.1111\/bjh.18777","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T20:04:04Z","timestamp":1679774644000},"page":"1229-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute chest syndrome in adult patients with sickle cell disease: The relationship with the time to onset after hospital admission"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8348-0430","authenticated-orcid":false,"given":"Geoffrey","family":"Cheminet","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP, H\u00f4pital Europ\u00e9en Georges Pompidou, DMU ENDROMED, Service de M\u00e9decine Interne Centre National de R\u00e9f\u00e9rence de la dr\u00e9panocytose et autres maladies rares des globules rouges  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Service d'Informatique, de biostatistique et sant\u00e9 publique AP\u2010HP, H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamal","family":"Khimoud","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Europ\u00e9en Georges Pompidou, DMU ENDROMED, Service de M\u00e9decine Interne Centre National de R\u00e9f\u00e9rence de la dr\u00e9panocytose et autres maladies rares des globules rouges  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Ranque","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP, H\u00f4pital Europ\u00e9en Georges Pompidou, DMU ENDROMED, Service de M\u00e9decine Interne Centre 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