{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:53Z","timestamp":1791331253416,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Molecular recurrence (MRec) occurs in about half of all patients with chronic myeloid leukaemia (CML) who discontinue tyrosine kinase inhibitors (TKI) in sustained deep molecular response. A second TKI discontinuation has been attempted in some patients who regain the discontinuation criteria after resuming treatment. Nilotinib treatment affords faster and deeper molecular responses than imatinib as first\u2010line therapy. We prospectively evaluated the efficacy and safety of nilotinib (300\u2009mg twice daily) in chronic\u2010phase CML patients who experienced MRec, after imatinib discontinuation and analysed the probability of TFR after a new attempt in patients treated for 2\u2009years with sustained MR\n                    <jats:sup>4.5<\/jats:sup>\n                    for at least 1\u2009year. A total of 31 patients were included in the study between 2013 and 2018. Seven (23%) patients experienced serious adverse events after a median of 2\u2009months of nilotinib treatment leading to discontinuation of treatment. One patient was excluded from the study for convenience. Among the 23 patients treated for 2\u2009years with nilotinib, 22 maintained their molecular response for at least 1\u2009year (median: 22\u2009months) and stopped nilotinib. The TFR rates at 24 and 48\u2009months after nilotinib discontinuation were 59.1% (95% confidence interval [CI]: 41.7%\u201383.7%) and 42.1% (95% CI: 25%\u201371%) respectively (NCT #01774630).\n                  <\/jats:p>","DOI":"10.1111\/bjh.18796","type":"journal-article","created":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T19:19:07Z","timestamp":1680463147000},"page":"1116-1124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy and safety of nilotinib in chronic myeloid leukaemia patients who failed to achieve a treatment\u2010free remission period after imatinib discontinuation: Results of the French Nilo post\u2010\n                    <scp>STIM<\/scp>\n                    study"],"prefix":"10.1111","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-7243","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Dulucq","sequence":"first","affiliation":[{"name":"Laboratory of Hematology University Hospital of Bordeaux, H\u00f4pital Haut L\u00e9v\u00eaque  Pessac France"},{"name":"Groupe Fi\u2010LMC, Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Rigal\u2010Huguet","sequence":"additional","affiliation":[{"name":"Groupe Fi\u2010LMC, Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Hematology Department Institut Universitaire du Cancer, CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-4199","authenticated-orcid":false,"given":"Franck E.","family":"Nicolini","sequence":"additional","affiliation":[{"name":"Groupe Fi\u2010LMC, Centre L\u00e9on B\u00e9rard  Lyon 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