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We enrolled 530 consecutive newly diagnosed AML patients in our study, and we analysed the distribution pattern and prognostic role of <jats:italic>SETD2<\/jats:italic> mutation in AML. <jats:italic>SETD2<\/jats:italic> mutation was found to affect 6.3% of AML patients, and it frequently co\u2010occurred with <jats:italic>IDH2<\/jats:italic>, <jats:italic>NRAS<\/jats:italic> and <jats:italic>CEBPA<\/jats:italic> mutations. <jats:italic>SETD2<\/jats:italic>\u2010mutated patients saw excellent therapeutic responses but failed to gain better survival time than other patients. This could be because of the high recurrence and mortality in <jats:italic>SETD2<\/jats:italic>\u2010mutated patients who have additional mutations, such as <jats:italic>NRAS<\/jats:italic> mutation.<\/jats:p>","DOI":"10.1111\/bjh.18811","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T04:19:34Z","timestamp":1681186774000},"page":"111-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["New insights into the clinical characteristics of <scp><i>SETD2<\/i><\/scp>\u2010mutated acute myeloid leukaemia"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-8352","authenticated-orcid":false,"given":"Xiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology Changhai Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Department of Human Genetics Zhejiang University School of Medicine  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Liu","sequence":"additional","affiliation":[{"name":"Acornmed Biotechnology Co. 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