{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T09:48:54Z","timestamp":1767260934142,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2022YFA1103300"],"award-info":[{"award-number":["2022YFA1103300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>As the COVID\u201019 variant Omicron surge in Beijing, China, a better understanding of risk factors for adverse outcomes may improve clinical management in patients with haematological malignancies (HM) diagnosed with COVID\u201019. The study sample includes 412 cases, mainly represented by acute leukaemia, chronic myeloid leukaemia (CML), plasma cell disorders and lymphoma and chronic lymphocytic leukaemia. COVID\u201019 pneumonia was observed in 10.4% (43\/412) of patients, and severe\/critical illness was observed in 5.3% (22\/412). Among the 86 cases with advanced malignancies, 17.6% (12\/86) of patients developed severe\/critical COVID\u201019, which was significantly higher than reported in patients with stable malignancies (9\/326, 2.70%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Similarly, the advanced malignancy cohort had a higher mortality rate (9\/86, 10.5% vs. 0\/326, 0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and a poor 30\u2010day overall survival (OS) compared with the stable malignancy cohort (74.2% vs. 100.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Overall, nine patients (2.2%) died. The primary cause of death was progressive HM in four patients and a combination of both COVID\u201019 and HM in five patients. In the multivariable analysis, over 65\u2009years of age, comorbidities and advanced malignancy were correlated with severe\/critical COVID\u201019 in HM patients. This study sheds light on the poor outcomes among COVID\u201019 HM patients with the leading cause of advanced malignancy.<\/jats:p>","DOI":"10.1111\/bjh.18823","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T09:53:05Z","timestamp":1682329985000},"page":"31-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>COVID<\/scp>\u201019 infection in patients with haematological malignancies: A single\u2010centre survey in the latest Omicron wave in China"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2632-7218","authenticated-orcid":false,"given":"Xiaolu","family":"Zhu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology Peking University  Beijing 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