{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:14:40Z","timestamp":1781748880444,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obinutuzumab (GA101) is a humanized anti\u2010CD20 monoclonal antibody used in the treatment of B\u2010cell malignancies. Under rare occasions, obinutuzumab may induce acute and severe thrombocytopenia. However, little is known about this side effect, referred to as \u201cobinutuzumab\u2010induced acute thrombocytopenia\u201d (OIAT). Here, we report 2 cases of OIAT and review the literature to inform the management and outcome of this rare but life\u2010threatening complication. The first case is a 74 year\u2010 old woman who was treated with obinutuzumab\u2010Cyclophosphamide, Vincristine, Prednisone (CVP) for a previously untreated follicular lymphoma. This patient experienced an acute thrombocytopenia with a drop in her platelet count from 376\u2009G\/L to 3\u2009G\/L the day after treatment. The second case is a 44 year\u2010 old woman who was treated with obinutuzumab as a pre\u2010treatment dose (day\u20108) before glofitamab infusion as a 4th line therapy for mantle cell lymphoma. This patient experienced an acute thrombocytopenia with a drop in her platelet count from 76\u2009G\/L (due to splenomegaly and bone marrow involvement) to 3\u2009G\/L the day after treatment. OIAT is a rare but life\u2010threatening complication. Physicians should be aware of this adverse event to optimally detect and treat this complication.<\/jats:p>","DOI":"10.1111\/bjh.18826","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T07:09:59Z","timestamp":1683270599000},"page":"168-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Obinutuzumab\u2010induced acute thrombocytopenia: Report of two cases and review of literature"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1978-7291","authenticated-orcid":false,"given":"Yaquine","family":"Mechelfekh","sequence":"first","affiliation":[{"name":"Department of Hematology, CHU de Rennes Universit\u00e9 de Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Pontrucher","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, CHU d'Angers Universit\u00e9 d'Angers  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Paillassa","sequence":"additional","affiliation":[{"name":"Department of Hematology, CHU d'Angers Universit\u00e9 d'Angers  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Temple","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Cochin Hospital, Assistance Publique H\u00f4pitaux de Paris\u2010Centre Universit\u00e9 Paris Cit\u00e9 (APHP\u2010CUP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-8213","authenticated-orcid":false,"given":"Roch","family":"Houot","sequence":"additional","affiliation":[{"name":"Department of Hematology, CHU de Rennes Universit\u00e9 de Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313984"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614598"},{"key":"e_1_2_9_4_1","unstructured":"European Medicines Agency.Gazyvaro (Obinutuzumab): Summary of Product Characteristics.2016."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30097-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25714"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9628-17"},{"key":"e_1_2_9_8_1","unstructured":"U.S. FDA. [Last accessed on 2022 Dec 26]. Available from:https:\/\/clinicaltrials.gov\/ProvidedDocs\/71\/NCT02596971\/Prot_SAP_000.pdf"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.42"},{"issue":"8","key":"e_1_2_9_10_1","article-title":"Successful use of intravenous immunoglobulins in an obinutuzumab\u2010related acute thrombocytopenia","volume":"6","author":"Haage TR","year":"2022","journal-title":"Hema"},{"issue":"11","key":"e_1_2_9_11_1","first-page":"1616","article-title":"Acute thrombocytopenia after obinutuzumab administration in a patient with relapsed follicular lymphoma","volume":"61","author":"Sakai K","year":"2020","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra066469"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.01.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03360.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.810620"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0476-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8737"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.18826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T10:31:09Z","timestamp":1699612269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.18826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/bjh.18826"],"URL":"https:\/\/doi.org\/10.1111\/bjh.18826","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]},"assertion":[{"value":"2023-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}