{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:48:15Z","timestamp":1765039695531,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070192"],"award-info":[{"award-number":["82070192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autologous haematopoietic stem cell transplantation (auto\u2010HSCT) as a treatment for B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL) has been rigorously debated in recent years. We retrospectively analysed the outcomes of 355 adult patients with B\u2010ALL in first complete remission who had received auto\u2010HSCT or allogeneic HSCT (allo\u2010HSCT) in our centre. The treatment efficacy was evaluated from a model stratified on the risk classification and minimal residue disease (MRD) status after three chemotherapy cycles. Auto\u2010HSCT demonstrated comparable 3\u2010year overall survival (OS) (72.7% vs. 68.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.441) and leukaemia\u2010free survival rates (62.8% vs. 56.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.383) compared to allo\u2010HSCT for patients with negative MRD, while the advantage of lower non\u2010relapse mortality (1.5% vs. 25.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was offset by a higher cumulative incidence of relapse (CIR) rates (35.7% vs. 18.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.018), especially in high\u2010risk patients. For patients at high risk and with positive MRD, there was a lower trend of 3\u2010year OS (50.0% vs. 66.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.078) and significantly higher CIR rates (71.4% vs. 39.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) in auto\u2010HSCT. However, no significant interaction was observed in the tests. In conclusion, auto\u2010HSCT appears to be an attractive treatment for patients with negative MRD after three chemotherapy cycles. For MRD\u2010positive patients, allo\u2010HSCT may be a more effective treatment.<\/jats:p>","DOI":"10.1111\/bjh.18846","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T05:05:52Z","timestamp":1683608752000},"page":"369-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes of allogeneic or autologous stem cell transplantation followed by maintenance chemotherapy in adult patient with <scp>B\u2010ALL<\/scp> in <scp>CR1<\/scp> with no detectable minimal residual disease"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-017X","authenticated-orcid":false,"given":"Mengnan","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology &amp; Blood Diseases Hospital, Chinese Academy 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