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The impact on outcome was investigated for each locus individually, combined as CNA profiles and together with cytogenetic information. The presence of <jats:italic>IKZF1<\/jats:italic> deletion or a poor\u2010risk CNA profile was associated with poor outcome in the whole cohort. In the standard\u2010risk group, <jats:italic>IKZF1<\/jats:italic>\u2010deleted cases had an inferior probability of relapse\u2010free survival (pRFS) (<jats:italic>p\u2009\u2264<\/jats:italic>\u20090.001) and overall survival (pOS) (<jats:italic>p\u2009\u2264<\/jats:italic>\u20090.001). Additionally, among B\u2010other patients, <jats:italic>IKZF1<\/jats:italic> deletion correlated with poor pRFS (60% vs. 90%) and pOS (65% vs. 89%). Both <jats:italic>IKZF1<\/jats:italic> deletion and a poor\u2010risk CNA profile were independent factors for relapse and death in multivariable analyses adjusting for known risk factors including measurable residual disease. Our data indicate that BCP\u2010ALL patients with high\u2010risk CNA or <jats:italic>IKZF1<\/jats:italic> deletion have worse prognosis despite otherwise low\u2010risk features. Conversely, patients with both a good CNA and cytogenetic profile had a superior relapse\u2010free (<jats:italic>p\u2009\u2264<\/jats:italic>\u20090.001) and overall survival (<jats:italic>p\u2009\u2264<\/jats:italic>\u20090.001) in the cohort, across all risk groups. Taken together, our findings highlight the potential of CNA assessment to refine stratification in ALL.<\/jats:p>","DOI":"10.1111\/bjh.18852","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:55:22Z","timestamp":1683593722000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The prognostic impact of <i>IKZF1<\/i> deletions and <scp>UKALL<\/scp> genetic classifiers in paediatric B\u2010cell precursor acute lymphoblastic leukaemia treated according to <scp>NOPHO<\/scp> 2008 protocols"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6907-8004","authenticated-orcid":false,"given":"Ingegerd","family":"\u00d6fverholm","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery and Centre for Molecular Medicine Karolinska Institute  Stockholm 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