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We report the characteristics and outcomes of five MPN\u2010BP patients treated with a never\u2010before\u2010described combination of azacytidine and venetoclax (to control BP transformation), added to ruxolitinib (needed to control constitutional symptoms). Median age was 76\u2009years (range 72\u201384), and worst performance status was 2. The overall response rate was 80%, and the complete remission rate was 40%. With median follow\u2010up of 10.0\u2009months (range 4.2\u201313.4), median overall survival was 13.4\u2009months (95% CI 4.2\u201313.4). We did not detect any unexpected treatment\u2010related toxicity, and quality of life was improved.<\/jats:p>","DOI":"10.1111\/bjh.18853","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T04:58:55Z","timestamp":1684126735000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Combination of azacitidine, venetoclax and ruxolitinib in blast phase myeloproliferative neoplasms"],"prefix":"10.1111","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0507-1740","authenticated-orcid":false,"given":"Thomas","family":"Systchenko","sequence":"first","affiliation":[{"name":"Haematology Department CHU de Poitiers  Poitiers 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